Neural representations of skilled movement
Neural representations of skilled movement
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DOI：
10.1093/brain/123.11.2306
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发表时间：
2000-11-01
期刊：
影响因子：
14.5
通讯作者：
Knight, RT
中科院分区：
文献类型：
--
作者：
Haaland, KY;Harrington, DL;Knight, RT
额叶皮层和顶叶皮层密切参与目标导向运动的表征，但人类的关键神经解剖部位还没有很好地建立起来。为了更精确地识别这些部位，我们研究了患有典型的意念性肢体失用症综合征的中风患者，这种失用症会破坏目标导向的运动，如书写或刷牙。通过评估模仿手势的错误并指定相对于正常对照组的失用症截止值，然后，我们使用MRI或CT进行病变定位，并比较有和没有肢体失用症的患者的重叠区域。同侧肢体失用症患者的左侧大脑半球网络受损，涉及额中回和顶内沟区域。因此，研究结果表明，人类左半球的离散区域对于控制复杂的目标导向运动至关重要。
The frontal and parietal cortex are intimately involved in the representation of goal-directed movements, but the crucial neuroanatomical sites are not well established in humans. In order to identify these sites more precisely, we studied stroke patients who had the classic syndrome of ideomotor limb apraxia, which disrupts goal-directed movements, such as writing or brushing teeth, Patients with and without limb apraxia were identified by assessing errors imitating gestures and specifying a cut-off for apraxia relative to a normal control group, We then used MRI or CT for lesion localization and compared areas of overlap in those patients with and without limb apraxia, Patients with ideomotor limb apraxia had damage lateralized to a left hemispheric network involving the middle frontal gyrus and intraparietal sulcus region. Thus, the results revealed that discrete areas in the left hemisphere of humans are critical for control of complex goal-directed movements.