Oxidative and Enantioselective Cross-Coupling of Aldehydes and Nitromethane Catalyzed by Diphenylprolinol Silyl Ether
Oxidative and Enantioselective Cross-Coupling of Aldehydes and Nitromethane Catalyzed by Diphenylprolinol Silyl Ether
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DOI：
10.1002/anie.201006885
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发表时间：
2011-01-01
影响因子：
16.6
通讯作者：
Ishikawa, Hayato
中科院分区：
文献类型：
--
作者：
Hayashi, Yujiro;Itoh, Takahiko;Ishikawa, Hayato
分别以2，3-二氯-5，6-二氰基醌（DDQ）和二苯基脯氨醇硅基醚为氧化剂和催化剂，通过β-芳基取代醛或γ-不饱和醛与硝基甲烷的交叉偶联反应，以优异的对映选择性合成了重要的β-取代γ-硝基醛。
Synthetically important β-substituted γ-nitro aldehydes have been synthesized with excellent enantioselectivity by the cross-coupling reaction of β-aryl substituted aldehydes or Y γ-unsaturated aldehydes and nitromethane using 2, 3-dichloro-5, 6-dicyanoquinone (DDQ) and diphenylprolinol silyl ether as an oxidant and catalyst, respectively (see scheme; TMS= trimethylsilyl).