Are nanostructured lipid carriers (NLCs) better than solid lipid nanoparticles (SLNs): Development, characterizations and comparative evaluations of clotrimazole-loaded SLNs and NLCs?
Are nanostructured lipid carriers (NLCs) better than solid lipid nanoparticles (SLNs): Development, characterizations and comparative evaluations of clotrimazole-loaded SLNs and NLCs?
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DOI：
10.1016/j.ejps.2012.05.010
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发表时间：
2012-08-30
影响因子：
4.6
通讯作者：
Tan, Reginald B. H.
中科院分区：
文献类型：
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作者：
Das, Surajit;Ng, Wai Kiong;Tan, Reginald B. H.
近年来，固体脂质纳米粒（SLN）和纳米结构脂质载体（NLC）是亲脂性药物给药的研究热点之一。尽管SLN作为药物载体已经表现出几种有益的特性，但有限的药物装载和储存期间药物的排出导致了NLC的发展。然而，由于相互矛盾的结果，NLC优于SLN的优势尚未完全确立。本研究以克霉唑为模型药物，构建SLN和NLC。比较了SLN和NLC的粒径、多分散指数（PI）、ZP、载药量（L）、包封率（EE）、扫描电镜（SEM）、差示扫描量热法（DSC）、X射线衍射（XRD）、药物释放和稳定性。关键工艺参数对纳米颗粒的性质具有显著影响。SLN和NLC的大小、PI、ZP和EE分别为
In recent years, solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are among the popular research topics for the delivery of lipophilic drugs. Although SLNs have demonstrated several beneficial properties as drug-carrier, limited drug-loading and expulsion of drug during storage led to the development of NLCs. However, the superiority of NLCs over SLNs has not been fully established yet due to the contradictory results. In this study, SLNs and NLCs were developed using clotrimazole as model drug. Size, polydispersity index (PI), zeta potential (ZP), drug-loading (L), drug encapsulation efficiency (EE), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffractometry (XRD), drug release and stability of SLNs and NLCs were compared. Critical process parameters exhibited significant impact on the nanoparticles' properties. Size, PI, ZP and EE of the developed SLNs and NLCs were