Genetic variation in DTNBP1 influences general cognitive ability
Genetic variation in DTNBP1 influences general cognitive ability
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DOI：
10.1093/hmg/ddi481
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发表时间：
2006-05-15
影响因子：
3.5
通讯作者：
Malhotra, AK
中科院分区：
文献类型：
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作者：
Burdick, KE;Lencz, T;Malhotra, AK
人类智力是一种已知受遗传因素显著影响的性状，最近的连锁数据提供了位置证据，表明染色体6p上的一个区域，以前与精神分裂症有关，可能与智力变异有关。dysbindin-1（DTNBP 1）的基因位于6p，也与精神分裂症有关，精神分裂症是一种以认知功能障碍为特征的神经精神疾病。我们报告了两个独立队列中DTNBP 1基因型与一般认知能力（g）之间的关联，包括213例精神分裂症或情感障碍患者和126例健康志愿者。这些数据表明，DTNBP 1基因变异影响人类智力。
Human intelligence is a trait that is known to be significantly influenced by genetic factors, and recent linkage data provide positional evidence to suggest that a region on chromosome 6p, previously associated with schizophrenia, may be linked to variation in intelligence. The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been implicated in schizophrenia, a neuropsychiatric disorder characterized by cognitive dysfunction. We report an association between DTNBP1 genotype and general cognitive ability (g) in two independent cohorts, including 213 patients with schizophrenia or schizo-affective disorder and 126 healthy volunteers. These data suggest that DTNBP1 genetic variation influences human intelligence.