Comparison of lipid-rich necrotic core size in symptomatic and asymptomatic carotid atherosclerotic plaque: Initial results
Comparison of lipid-rich necrotic core size in symptomatic and asymptomatic carotid atherosclerotic plaque: Initial results
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DOI：
10.1002/jmri.21359
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发表时间：
2008-06-01
影响因子：
4.4
通讯作者：
Kooi, M. Eline
中科院分区：
文献类型：
--
作者：
Cappendijk, Vincent C.;Kessels, Alfons G. H.;Kooi, M. Eline
目的：研究有症状患者与无症状患者颈动脉斑块中富脂坏死核心（LRNC）大小的潜在差异。病理学研究表明，大的LRNC是易损动脉粥样硬化斑块的重要特征。在此之前，我们已经证明了LRNC的大小在T1加权（W）涡轮场回波（TFE）MR images和histologic.Materials和方法：37例颈动脉狭窄> 70%（n = 26）或无症状（n = 11）的半定量分析之间的高度相关性。三名独立的MR读片员使用T1 w TFE脉冲序列定量LRNC的量。LRNC的相对量（LRNC评分）被定义为横截面积百分比LRNC每carotid plaic.Results的总和：Interreader协议的三个MR读者是好的，与组内相关系数（ICC，95%置信区间[CI]）为0.72（0.57-0.83）。所有三位MR阅片师平均发现有症状组患者的LRNC较大，尽管这在统计学上不显著。有症状和无症状患者的平均LRNC评分分别为116 +/- 129和59 +/- 62（P = 0.13）。有症状组LRNC评分范围较宽（0-424分），无症状组LRNC评分范围较低（0-170分）。结论：单序列T1 w TFE是研究动脉粥样硬化斑块与卒中风险的一种有前途的技术。需要更大规模的研究来证实这些有希望的结果。
Purpose: To investigate the potential difference in the size of the lipid-rich necrotic core (LRNC) in carotid plaques of symptomatic patients versus asymptomatic patients. Pathological studies established that a large LRNC is an important feature of vulnerable atherosclerotic plaque. Previously, we have demonstrated a high correlation between semiquantitative analysis of the LRNC size in T1-weighted (w) turbo field echo (TFE) MR images and histology.Materials and Methods: Thirty-seven patients with carotid stenosis > 70% with (n = 26) or without (n = 11) symptoms were included. Three independent MR readers quantified the amount of LRNC with a T1w TFE pulse sequence. The relative amount of LRNC (LRNC score) was defined as sum of cross-sectional area percentages LRNC per carotid plaque.Results: Interreader agreement for the three MR readers was good, with an intraclass correlation coefficient (ICC, 95% confidence interval [CI]) of 0.72 (0.57-0.83). All three MR readers on average found a larger LRNC in the symptomatic group of patients, although this was not statistically significant. The mean LRNC score was 116 +/- 129 and 59 +/- 62 for symptomatic and asymptomatic patients, respectively (P = 0.13). Symptomatic patients showed wide ranges in LRNC scores (0-424), while the range was much lower in the asymptomatic group (0-170).Conclusion: Single-sequence T1w TFE may be a promising technique to study atherosclerotic plaque at risk of stroke. Larger studies are warranted to confirm these promising results.