ESCRT-III Assembly and Cytokinetic Abscission Are Induced by Tension Release in the Intercellular Bridge
ESCRT-III Assembly and Cytokinetic Abscission Are Induced by Tension Release in the Intercellular Bridge
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DOI：
10.1126/science.1233866
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发表时间：
2013-03-29
期刊：
影响因子：
56.9
通讯作者：
Piel, Matthieu
中科院分区：
文献类型：
--
作者：
Lafaurie-Janvore, Julie;Maiuri, Paolo;Piel, Matthieu
细胞分裂的最后一步是胞质分裂，产生两个通过细胞间桥梁连接的子细胞。这种状态通常代表着分裂过程中最长的阶段。切断桥梁(脱落)需要一系列描述良好的分子事件，但脱落的触发因素仍不清楚。我们发现，子代细胞施加在细胞间桥上的拉力似乎调节了脱落。与直觉相反的是，这些力量延长了连接，而释放张力则导致了分离。张力释放触发了ESCRT-III(运输所需的内体分选复合体)的组装，随后是膜分裂。这种机制可能允许子代细胞保持连接，直到它们在最终位置安顿下来，这一过程对组织组织和形态发生具有潜在的重要意义。
The last step of cell division, cytokinesis, produces two daughter cells that remain connected by an intercellular bridge. This state often represents the longest stage of the division process. Severing the bridge (abscission) requires a well-described series of molecular events, but the trigger for abscission remains unknown. We found that pulling forces exerted by daughter cells on the intercellular bridge appear to regulate abscission. Counterintuitively, these forces prolonged connection, whereas a release of tension induced abscission. Tension release triggered the assembly of ESCRT-III (endosomal sorting complex required for transport-III), which was followed by membrane fission. This mechanism may allow daughter cells to remain connected until they have settled in their final locations, a process potentially important for tissue organization and morphogenesis.