ACUTE RESPIRATORY ILLNESS IN NURSERY SCHOOL CHILDREN - A LONGITUDINAL STUDY OF OCCURRENCE OF ILLNESS AND RESPIRATORY VIRUSES
ACUTE RESPIRATORY ILLNESS IN NURSERY SCHOOL CHILDREN - A LONGITUDINAL STUDY OF OCCURRENCE OF ILLNESS AND RESPIRATORY VIRUSES
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DOI：
10.1093/oxfordjournals.aje.a121047
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发表时间：
1969-01-01
影响因子：
5
通讯作者：
BEEM, MO
中科院分区：
文献类型：
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作者：
BEEM, MO
Beem, M. O.（芝加哥大学儿科，芝加哥，III. 60637）。幼儿园儿童的急性呼吸道疾病：疾病发生和呼吸道病毒的纵向研究。美国。 J. Epid., 1969, 90: 30–44.——从 1962 年 11 月到 1963 年 8 月，对日托幼儿园的 3 至 5 岁儿童进行了观察，以确定呼吸道感染的发病率以及流感、副流感、呼吸道合胞病毒、腺病毒和小核糖核酸病毒在这些感染中所起的作用。观察到的急性疾病发病率大大超过了家庭环境中同龄儿童的记录，急性呼吸道疾病占儿童患病总数的绝大多数。发现了腺病毒、副流感病毒和流感病毒的感染，但就通过病毒分离可以确定的程度而言，这些病毒似乎并未在该群体中广泛传播。尽管血清学证据表明大多数儿童之前曾感染过呼吸道合胞体 (RS) 病毒，但呼吸道合胞 (RS) 病毒的引入导致了广泛的病毒传播和疾病。鼻病毒感染是最常见的呼吸道疾病病因，在确定病因的急性呼吸道疾病中，鼻病毒感染所占的比例比所有其他病毒的总和还要大。这些感染一年四季都有发生，由 14 种不同的鼻病毒血清型引起。鼻病毒传播的程度存在很大差异。引入该组的一半血清型没有检测到传播。另外七种病毒传播给一名或多名儿童，其中三种病毒传播范围相当广泛，感染了 42% 至 77% 的儿童。呼吸道疾病与鼻病毒脱落有明显的关联。
Beem, M. O. (Dept. Pediatrics, Univ. of Chicago, Chicago, III. 60637). Acute respiratory illness in nursery school children: a longitudinal study of the occurrence of illness and respiratory viruses.Amer. J. Epid., 1969, 90: 30–44.—Children, aged three to five years, attending a day care nursery school were observed from November, 1962 to August, 1963 to determine the incidence of respiratory infections and the role played in these by influenza, parainfiuenza, respiratory syncytial, adeno and picoma viruses. The observed incidence of acute illness considerably exceeded that recorded for children of a similar age in household settings, and acute respiratory illness accounted for the overwhelming majority of the total illness experienced by the children. Infections with adeno, para-influenza and influenza viruses were identified, but to the extent that could be determined by virus isolation these did not appear to spread widely through the group. Introduction of respiratory syncytial (RS) virus resulted in extensive virus spread and illness, in spite of the fact that serotogic evidence indicated the majority of the children had experienced previous RS virus infections. Rhinovirus infections were the most frequently identified cause of respiratory illness accounting for a larger portion of the acute respiratory illness of defined etiology than all other viruses combined. These infections occurred in all seasons of the year and were caused by 14 different rhinovirus serotypes. There was great variation in the extent to which rhinoviruses spread. Half of the serotypes introduced into the group underwent no detected spread. The other seven spread to one or more children, and three of these spread quite extensively, infecting from 42 to 77% of the children. There was a clear association of respiratory illness with rhinovirus shedding.