Spinal and Supraspinal Processing of Thermal Stimuli: An fMRI Study
Spinal and Supraspinal Processing of Thermal Stimuli: An fMRI Study
复制标题
DOI：
10.1002/jmri.24627
复制
发表时间：
2015-04-01
影响因子：
4.4
通讯作者：
Gierthmuehlen, Janne
中科院分区：
文献类型：
--
作者：
Rempe, Torge;Wolff, Stephan;Gierthmuehlen, Janne
目的利用功能性脊髓磁共振成像（spinal fMRI）评估和表征对无害/有害热刺激和热异常性痛的反应。材料与方法采用fMRI （3T，单次TSE， TR 9000 msec, TE 38 msec, FOV 288 × 144 × 20 mm，基质192 × 96，体素大小1 × 1 × 2 mm）对16名健康受试者的皮节C6基线和致敏后的疼痛和非疼痛热刺激进行脊髓/棘上激活模式的研究。结果在毒热和热异常痛时，对侧和对侧脊髓前背角的活动增加。在毒热期间，但在热异常性疼痛期间，在导水管周围灰质、同侧楔形核和同侧背外侧桥状被（DLPT）中可见激活。然而，在热异常性疼痛期间，在双侧橡胶核、对侧DLPT和延髓喙侧腹内侧（RVM）观察到激活。对侧背网状亚核（SRD）在毒热和热异常性痛时均可见激活(tbbb2.5， P
PurposeTo assess and characterize responses to innocuous/noxious thermal stimuli and heat allodynia using functional spinal magnetic resonance imaging (spinal fMRI).Materials and MethodsSpinal/supraspinal activation patterns of 16 healthy subjects were investigated by applying painful and nonpainful heat stimuli to dermatome C6 baseline and after sensitization with the heat/capsaicin model using fMRI (3T, single-shot TSE, TR 9000 msec, TE 38 msec, FOV 288 x 144 x 20 mm, matrix 192 x 96, voxel size 1 x 1 x 2 mm).ResultsIncreased activity was observed in ipsi- and contralateral ventral and dorsal spinal horn during noxious heat and heat allodynia. During noxious heat, but not during heat allodynia, activations were visible in the periaqueductal gray, ipsilateral cuneiform nucleus, and ipsilateral dorsolateral pontine tegmentum (DLPT). However, during heat allodynia activations were observed in bilateral ruber nuclei, contralateral DLPT, and rostral ventromedial medulla oblongata (RVM). Activations in contralateral subnucleus reticularis dorsalis (SRD) were visible during both noxious heat and heat allodynia (T >2.5, P