[Study on incompatibility of traditional Chinese medicines].
[Study on incompatibility of traditional Chinese medicines].
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DOI：
10.4268/cjcmm20150839
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发表时间：
2015-04
期刊：
影响因子：
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通讯作者：
Xin-Sheng Fan;J. Duan;Hao-ming Hua;D. Qian;E. Shang;Jianming Guo
中科院分区：
文献类型：
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作者：
Xin-Sheng Fan;J. Duan;Hao-ming Hua;D. Qian;E. Shang;Jianming Guo
中药配伍问题关系到临床用药安全，引起了社会各界的广泛关注。随着对以18种配伍药为代表的中药配伍研究的深入，理论中医配伍问题上升到一个新的高度。从中医配伍理论的起源、中草药的相互关系、配伍的危害以及对特定配伍药物毒性作用的预防原理等方面，探讨了中医配伍理论的创新与发展。从结构上讲，中医的不相容是指基于七种情绪和临床经验的两种草药的对立。中草药混用可能对人体造成危害，尤其是干预药物的潜在危害和无效。避免配伍，兼顾症状和药效，是预防不良反应的基本方法。近年来的研究揭示了配伍药的五个特点。毒性增强、毒化、减效、失效是不相容关系的四种表现。物质变化可以反映对生药材的增毒作用和毒性作用。毒性积累和代谢变化是潜在危害的基础。主要功效的拮抗作用和正负作用的并存是其不相容的显著特征。中药配伍的内涵对中医配伍理论的创新具有重要意义。
The incompatibility of traditional Chinese medicines is related to the clinical medication safety, so has attracted wide attentions from the public. With the deepening of studies on the incompatibility of traditional Chinese medicines represented by 18 incompatible herbs, the incompatibility of theory traditional Chinese medicines has raised to new heights. From the origin of incompatibility theory of traditional Chinese medicines, relationship of herbs, harms of incompatible herbs and principle of prevention to toxic effects of specific incompatible medicines, the innovation and development of the traditional Chinese medicine incompatibility theory was explored. Structurally, the incompatibility of traditional Chinese medicines refers to the opposition of two herbs based on seven emotions and clinical experience. The combination of incompatible herbs may lead to human harms, especially latent harm and inefficacy of intervention medicines. The avoidance of the combination of incompatible herbs and the consideration of both symptoms and drug efficacy are the basic method to prevent adverse reactions. The recent studies have revealed five characteristics of incompatible herbs. Toxicity potentiation, toxication, efficacy reduction and inefficacy are the four manifestations of the incompatible relations. The material changes can reflect the effects of toxicity potentiation and toxication of opposite herbs. The accumulation of toxicity and metabolic changes are the basis for latent harms. The antagonistic effect of main efficacies and the coexistence of positive and negative effects are the distinctive part of the incompatibility. The connotation of incompatible herbs plays an important role in the innovation of the traditional Chinese medicine incompatibility theory.