LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells
LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells
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DOI：
10.1016/j.jphs.2016.07.006
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发表时间：
2016-11-01
影响因子：
3.5
通讯作者：
Anzai, Naohiko
中科院分区：
文献类型：
--
作者：
Hayashi, Keitaro;Jutabha, Promsuk;Anzai, Naohiko
L型氨基酸转运蛋白1（LAT 1，SLC 7A 5）将必需氨基酸整合到细胞中。最近的研究表明，LAT 1是各种人类癌症中的主要转运蛋白。然而，LAT 1在胸腺癌中的功能仍不清楚。在这里，我们证明，LAT 1是一个关键的转运人胸腺癌细胞。LAT 1在人胸腺癌组织中呈强表达。LAT 1特异性抑制剂显著抑制Ty 82人胸腺癌细胞系的亮氨酸摄取和生长，表明胸腺癌利用LAT 1作为质量转运蛋白，并且LAT 1特异性抑制剂可能在临床上有益于胸腺癌的治疗。(C)2016作者Elsevier B. V.代表日本药理学会制作和主办。这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
L-type amino acid transporter 1 (LAT1, SLC7A5) incorporates essential amino acids into cells. Recent studies have shown that LAT1 is a predominant transporter in various human cancers. However, the function of LAT1 in thymic carcinoma remains unknown. Here we demonstrate that LAT1 is a critical transporter for human thymic carcinoma cells. LAT1 was strongly expressed in human thymic carcinoma tissues. LAT1-specific inhibitor significantly suppressed leucine uptake and growth of Ty82 human thymic carcinoma cell lines, suggesting that thymic carcinoma takes advantage of LAT1 as a quality transporter and that LAT1-specific inhibitor might be clinically beneficial in therapy for thymic carcinoma. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).