The analysis of streptococcal infections. VI. Immunoelectrophoretic observations on extracellular antigens detectable with human antibodies.
The analysis of streptococcal infections. VI. Immunoelectrophoretic observations on extracellular antigens detectable with human antibodies.
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DOI：
10.1084/jem.113.6.1013
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发表时间：
1961-06-01
期刊：
影响因子：
--
通讯作者：
KEATINGE SL
中科院分区：
文献类型：
--
作者：
HALBERT SP;KEATINGE SL
通过免疫电泳发现，A组链球菌在人体组织中释放至少20种不同的细胞外抗原，这是通过正常混合人丙种球蛋白中存在的天然抗体来判断的。这些沉淀素弧中的几个已被鉴定为具有先前通过电泳和色谱法纯化的链球菌抗原。与通过用几种链球菌滤液进行超免疫获得的四种马抗体浓缩物相比，人γ球蛋白以及几种风湿热血清在抗链球菌抗体方面显着有效。C组链球菌培养浓缩物显示8或9种抗原，其相应的抗体存在于人γ球蛋白中。
It has been found by immunoelectrophoresis, that Group A streptococci release at least 20 distinct extracellular antigens in human tissues, as judged by naturally occurring antibodies present in normal pooled human gamma globulin. Several of these precipitin arcs have been identified with streptococcal antigens previously purified by electrophoresis and chromatography. Human gamma globulin, as well as several rheumatic fever sera, were shown to be remarkably potent in antistreptococcal antibodies, when compared to four horse antibody concentrates obtained by hyperimmunization with several streptococcal filtrates. A Group C streptococcal culture concentrate revealed 8 or 9 antigens for which corresponding antibodies were present in human gamma globulin.