False Recognition in Alzheimer Disease: Evidence from Categorized Pictures
False Recognition in Alzheimer Disease: Evidence from Categorized Pictures
复制标题
DOI：
10.1097/00146965-200303000-00003
复制
发表时间：
2003-03-01
影响因子：
1.4
通讯作者：
Schacter, Daniel L.
中科院分区：
文献类型：
--
作者：
Budson, Andrew E.;Michalska, Kalina J.;Schacter, Daniel L.
目的：利用分类彩色照片范式，更好地了解阿尔茨海默病(AD)患者的记忆扭曲和错误再认。背景：先前的研究发现，AD患者和老年人对语义联系和知觉相关的新物体的未纠正错误再认水平相似。结果：AD患者的未纠正错误再认水平高于老年人。方法：对24例AD患者和24名年龄、教育程度和性别相匹配的老年人进行了错误再认研究。结果：与老年人相比，AD患者有更高的未纠正错误再认水平。结论：这些结果可能是由于AD患者同时获得主旨信息和项目特定信息的能力较差，以及这些患者固有的额叶功能障碍导致难以抑制仅基于熟悉的反应。
Objectives:To better understand memory distortions and false recognition in patients with Alzheimer disease (AD), using a paradigm of categorized color photographs.Background:Previous research has found that patients with AD and older adults showed similar levels of uncorrected false recognition of semantic associates and of perceptually related novel objects. In contrast to these results, using a paradigm in which semantically related words were accompanied by black and white line drawings, it was found that patients with AD showed a trend toward higher levels of uncorrected false recognition compared with older adults.Methods:To explore this trend, 24 patients with AD and 24 older adults matched for age, education, and gender were examined using a false recognition paradigm consisting of categorized color photographs (e. g., flowers, motorcycles, cats).Results:Compared with older adults, patients with AD showed higher levels of uncorrected false recognition, but lower levels of corrected false recognition and lower levels of item-specific recollection.Conclusions:The authors suggest that these results may be attributable to the poor ability of patients with AD to acquire both gist and item-specific information as well as these patients' inherent frontal lobe dysfunction leading to difficulty inhibiting responses on the basis of familiarity alone.