Spontaneously hypertensive, Wistar Kyoto and Sprague-Dawley rats differ in their use of place and response strategies in the water radial arm maze
Spontaneously hypertensive, Wistar Kyoto and Sprague-Dawley rats differ in their use of place and response strategies in the water radial arm maze
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DOI：
10.1016/j.nlm.2006.09.003
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发表时间：
2007-02-01
影响因子：
2.7
通讯作者：
Wainwright, P. E.
中科院分区：
文献类型：
--
作者：
Clements, K. M.;Saunders, A. J.;Wainwright, P. E.
本研究进一步描述了记忆系统在自发性高血压大鼠（SHR）中的应用，SHR经常被用作注意缺陷多动障碍的啮齿动物模型。本研究的目的是评估雄性SHR，Wistar-Kyoto（WKY）和Sprague-Dawley（SD）大鼠在模糊T迷宫任务训练时对位置或反应策略的偏好，并检查所有品系在模糊训练期间是否获得了关于这两种策略的信息，无论其偏好的策略如何。在第一个实验中，SHR和WKY表现出对模糊T-迷宫任务的反应策略的偏好;相反，SD表现出对位置策略的偏好。在第二个实验中，所有的菌株都表明，他们在模糊训练中学习了关于反应和位置策略的信息。然而，在条件性位置偏好测试中，SHR没有表现出像WKY和SD那样对位置臂的强烈偏好。这一发现支持了以前的研究在条件提示偏好测试，其中SHR没有显示出与平台相关的提示的偏好。这些观察结果表明，在学习任务中，菌株的行为策略不同，这表明它们在为目标导向行为服务的潜在神经回路中不同，并且与SHR具有与丘脑核相关的缺陷一致。(c)2006年爱思唯尔公司All rights reserved.
This study further characterises the use of mnemonic systems in the spontaneously hypertensive rat (SHR), which is frequently used as a rodent model of attention deficit hyperactivity disorder. The objective of this study was to assess the preference of male SHR, Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rats for a place or response strategy when trained on an ambiguous T-maze task, and also to examine whether all strains acquired information about both strategies during ambiguous training, regardless of their preferred strategy. In the first experiment, SHR and WKY showed a preference for a response strategy on the ambiguous T-maze task; in contrast, SD displayed a preference for a place strategy. In the second experiment, all strains demonstrated that they learned information about both the response and place strategies during ambiguous training. However, on a conditioned place preference test SHR did not display as strong a preference for the place arm as WKY and SD. This finding supports previous research in a conditioned cue preference test, in which SHR did not display a preference for the cue associated with the platform. These observations that the strains differ with respect to behavioural strategy in a learning task suggest that they differ in the underlying neural circuitry that serves goal-directed behaviour, and are consistent with SHR having deficits associated with the nucleus accumbens. (c) 2006 Elsevier Inc. All rights reserved.