Construction of a biomechanical head and neck motion model as a guide to evaluation of deformable image registration
Construction of a biomechanical head and neck motion model as a guide to evaluation of deformable image registration
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DOI：
10.1088/1361-6560/aa69b6
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发表时间：
2017-05
影响因子：
3.5
通讯作者：
H. Teske;K. Bartelheimer;Jan Meis;R. Bendl;E. Stoiber;K. Giske
中科院分区：
文献类型：
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作者：
H. Teske;K. Bartelheimer;Jan Meis;R. Bendl;E. Stoiber;K. Giske
在自适应放射治疗的背景下使用可变形图像配准方法导致在治疗过程期间所施用剂量分布的模拟中的不确定性。对这些方法的评估是决定计划调整是否会改善个体治疗的先决条件。目前使用手动参考的方法限制了评估的有效性，特别是对于低对比度区域。特别是，对于头部和颈部区域，高度灵活的解剖结构和控制图像中的低软组织对比度对图像配准及其评价提出了挑战。生物力学模型有望通过提供患者的拟人化运动建模来克服这个问题。我们介绍了一种新的生物力学运动模型的生成和采样的头部和颈部解剖的不同姿势。各个骨骼的运动传播行为由底层运动学模型定义。该模型通过关节将骨骼互连，因此能够提供广泛的运动。由单个骨骼的运动触发，软组织变形由基于链甲方法的扩展异质组织模型描述。这种扩展首次允许在软组织内传播衰减旋转，而无需明确的组织分割。包括基本噪声模型在内的变形CT扫描的整体运动模拟和采样在30 s内实现。建议的生物力学运动模型的头部和颈部网站上生成的体素的基础上的位移矢量场，近似任意拟人化的病人的姿势。它的目的是提供输入数据的变形图像配准的评价。
The use of deformable image registration methods in the context of adaptive radiotherapy leads to uncertainties in the simulation of the administered dose distributions during the treatment course. Evaluation of these methods is a prerequisite to decide if a plan adaptation will improve the individual treatment. Current approaches using manual references limit the validity of evaluation, especially for low-contrast regions. In particular, for the head and neck region, the highly flexible anatomy and low soft tissue contrast in control images pose a challenge to image registration and its evaluation. Biomechanical models promise to overcome this issue by providing anthropomorphic motion modelling of the patient. We introduce a novel biomechanical motion model for the generation and sampling of different postures of the head and neck anatomy. Motion propagation behaviour of the individual bones is defined by an underlying kinematic model. This model interconnects the bones by joints and thus is capable of providing a wide range of motion. Triggered by the motion of the individual bones, soft tissue deformation is described by an extended heterogeneous tissue model based on the chainmail approach. This extension, for the first time, allows the propagation of decaying rotations within soft tissue without the necessity for explicit tissue segmentation. Overall motion simulation and sampling of deformed CT scans including a basic noise model is achieved within 30 s. The proposed biomechanical motion model for the head and neck site generates displacement vector fields on a voxel basis, approximating arbitrary anthropomorphic postures of the patient. It was developed with the intention of providing input data for the evaluation of deformable image registration.