Early childhood outcomes of NICU graduates with cytomegalovirus infection in California.
Early childhood outcomes of NICU graduates with cytomegalovirus infection in California.
复制标题
加利福尼亚州新生儿重症监护病房毕业生巨细胞病毒感染的早期儿童结局。
DOI：
10.1002/bdr2.2203
复制
发表时间：
2023
影响因子：
2.1
通讯作者：
Lee,HenryC
中科院分区：
文献类型：
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作者：
Lanzieri,TatianaM;Lu,Tianyao;Bennett,MihokoV;Hintz,SusanR;Sugerman,DavidE;Dollard,SheilaC;Pesch,MeganH;Jocson,MariaAL;Lee,HenryC
目的评估2010-2021年间加州新生儿重症监护病房(NICU)中感染巨细胞病毒(CMV)儿童的人口学特征和预后。方法加州围产期质量护理协作组收集加州92%新生儿重症监护室(NICU)中所有极低出生体重儿(VLBW，Birth Weight ≤ 1500 g)和危重婴儿 &Gt； 1500 g的数据。极低出生体重儿和有神经疾病的婴儿被转介到全州范围的高危婴儿随访(HRIF)计划。结果2010年至2021年间，巨细胞病毒报告发病率平均为3.5/1000极低出生体重儿(n= 205)和1.1/1000婴儿>；1500 g(n= 128)。在333例巨细胞病毒感染的婴儿中，314例(94%)活着出院，271例(86%)转诊为高危因素，205例(65%)接受了≥1次探视。20岁 的母亲所生的婴儿巨细胞病毒报告率最高，而拉美裔母亲所生的婴儿占所有感染婴儿的49%，但他们失去随访的几率最高。在12个月的随访中(n= 152)，19例(13%)巨细胞病毒携带者双眼失明，18例(12%)听力损失。在24个月的随访中，103名婴儿中有5名(5%)出现了严重的脑瘫。结论在NICU住院的婴儿中，CMV诊断的婴儿可能代表了更严重的CMV疾病和预后。CPQCC和HRIF项目的调查结果可能有助于在美国其他州实施先天性CMV感染的监测，并指导减少获得服务方面的差距的战略。
BackgroundTo assess demographics and outcomes up to 3 years of age among children with cytomegalovirus (CMV) infection in California neonatal intensive care units (NICUs) during 2010–2021.MethodsThe California Perinatal Quality Care Collaborative (CPQCC) collects data on all very low birth weight (VLBW, birth weight ≤ 1500 g) and acutely ill infants with birth weight > 1500 g across 92% of NICUs in California. VLBW infants and those with neurological conditions are referred to a statewide high‐risk infant follow‐up (HRIF) program. CMV infection was defined as a positive culture or PCR identified during the NICU hospitalization.ResultsDuring 2010–2021, CMV reporting rates averaged 3.5/1000 VLBW infants (n= 205) and 1.1/1000 infants >1500 g (n= 128). Among all 333 infants with CMV, 314 (94%) were discharged home alive, 271 (86%) were referred for HRIF and 205 (65%) had ≥1 visit. Whereas infants born to mothers <20 years of age had highest CMV reporting rates and those born to Hispanic mothers comprised 49% of all infected infants, they had the highest loss of follow‐up. At the 12‐month visit (n= 152), 19 (13%) infants with CMV had bilateral blindness and 18 (12%) had hearing loss. At the 24‐month visit, 5 (5%) of 103 had severe cerebral palsy.ConclusionsAmong infants admitted to the NICU, those with CMV diagnoses may over represent infants with more severe CMV disease and outcomes. The CPQCC and HRIF program findings may help inform implementation of surveillance for congenital CMV infection in other U.S. states and guide strategies to reduce disparities in access to services.