Remarkable shrinkage of sarcomatoid renal cell carcinoma with single-agent gemcitabine
Remarkable shrinkage of sarcomatoid renal cell carcinoma with single-agent gemcitabine
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DOI：
10.1097/cad.0b013e3282f5d336
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发表时间：
2008-04-01
影响因子：
2.3
通讯作者：
Tanimoto, Mitsune
中科院分区：
文献类型：
--
作者：
Fujiwara, Yoshiro;Kiura, Katsuyuki;Tanimoto, Mitsune
一位60岁的日本男性因左髋疼痛来我院就诊。电脑断层显示肿瘤在左肾和转移在左臀大肌肌肉和肺。病理诊断为肉瘤样肾细胞癌。入院时，他的总体状况极差。他因左髋严重疼痛和意识模糊（可能由高钙血症引起）而卧床不起。这名患有晚期肉瘤样肾细胞癌的重病患者接受吉西他滨单药治疗，症状缓解，病情显著改善;所有肿瘤在吉西他滨第11次给药时均显著消退。这些结果表明，单药吉西他滨是为数不多的化疗药物有效缓解肉瘤样肾细胞癌患者，即使是那些性能状态差。Anti-Cancer Drugs 19：431-433（c）2008 Wolters Kluwer Health垂直栏Lippincott威廉姆斯& Wilkins。
A 60-year-old Japanese man presented to our hospital with a painful left hip. Computed tomography showed a tumor in the left kidney and metastases in the left gluteus maximus muscle and lung. The pathological diagnosis of a biopsy specimen obtained from a metastatic lesion in the left gluteus maximus muscle was sarcomatoid renal cell carcinoma. On admission, his general condition was extremely poor. He was confined to bed because of severe left hip pain and confusion, possibly caused by hypercalcemia. This seriously ill patient suffering from advanced sarcomatoid renal cell carcinoma was treated with single-agent gemcitabine, resulting in symptom relief and a dramatic improvement in his status; all of the tumors had regressed significantly by the 11th dose of gemcitabine. These findings indicate that single-agent gemcitabine is one of the few chemotherapeutic agents effective for palliation in patients with sarcomatoid renal cell carcinoma, even those with poor performance status. Anti-Cancer Drugs 19:431-433 (c) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.