Tiny Regulators of Massive Tissue: MicroRNAs in Skeletal Muscle Development, Myopathies, and Cancer Cachexia.
Tiny Regulators of Massive Tissue: MicroRNAs in Skeletal Muscle Development, Myopathies, and Cancer Cachexia.
复制标题
DOI：
10.3389/fonc.2020.598964
复制
发表时间：
2020
影响因子：
4.7
通讯作者：
Wang DZ
中科院分区：
文献类型：
--
作者：
Singh GB;Cowan DB;Wang DZ
骨骼肌是我们身体中最大的组织，肌肉的生理功能对生活的各个方面都至关重要。发育、稳态和代谢的调节对于骨骼肌的正常功能至关重要。因此，了解肌发生的调控过程是非常有意义的。非编码RNA特别是microRNA（miRNAs）是基因表达和功能的重要调控因子。miRNAs是一种小的非编码RNA（约22个核苷酸长），在转录后负调控靶基因的表达，在骨骼肌中大量表达。功能获得和丧失研究揭示了这类小分子在肌肉生物学和疾病中的重要作用。本文综述了miRNAs在骨骼肌发育、基因表达和功能以及肌肉疾病如少肌症和杜氏肌营养不良症（DMD）中的作用。继续当前综述系列的主题，我们还简要讨论了miRNA在癌症恶病质中的作用。
Skeletal muscles are the largest tissues in our body and the physiological function of muscle is essential to every aspect of life. The regulation of development, homeostasis, and metabolism is critical for the proper functioning of skeletal muscle. Consequently, understanding the processes involved in the regulation of myogenesis is of great interest. Non-coding RNAs especially microRNAs (miRNAs) are important regulators of gene expression and function. MiRNAs are small (~22 nucleotides long) noncoding RNAs known to negatively regulate target gene expression post-transcriptionally and are abundantly expressed in skeletal muscle. Gain- and loss-of function studies have revealed important roles of this class of small molecules in muscle biology and disease. In this review, we summarize the latest research that explores the role of miRNAs in skeletal muscle development, gene expression, and function as well as in muscle disorders like sarcopenia and Duchenne muscular dystrophy (DMD). Continuing with the theme of the current review series, we also briefly discuss the role of miRNAs in cancer cachexia.
登录
查看更多内容
影响因子：
3.7
作者：
Cardinali B;Castellani L;Fasanaro P;Basso A;Alemà S;Martelli F;Falcone G
通讯作者：
Falcone G
影响因子：
15.9
作者：
Alexander, Matthew S.;Carlos Casar, Juan;Kunkel, Louis M.
通讯作者：
Kunkel, Louis M.
影响因子：
64.8
作者：
Chendrimada, TP;Gregory, RI;Shiekhattar, R
通讯作者：
Shiekhattar, R
影响因子：
3.5
作者：
Cao, Xinao;Tang, Shuyue;Yin, Huadong
通讯作者：
Yin, Huadong
影响因子：
--
作者：
D'Agostino M;Torcinaro A;Madaro L;Marchetti L;Sileno S;Beji S;Salis C;Proietti D;Imeneo G;C Capogrossi M;De Santa F;Magenta A
通讯作者：
Magenta A