WASP: Wearable Analytical Skin Probe for Dynamic Monitoring of Transepidermal Water Loss.
WASP: Wearable Analytical Skin Probe for Dynamic Monitoring of Transepidermal Water Loss.
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WASP：用于动态监测经皮水分流失的可穿戴分析皮肤探针。
DOI：
10.1021/acssensors.3c01936
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发表时间：
2023-11
期刊：
影响因子：
8.9
通讯作者：
A. D. Sivakumar;Ruchi Sharma;Chandrakalavathi Thota;Ding Ding-Ding;Xudong Fan
中科院分区：
文献类型：
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作者：
A. D. Sivakumar;Ruchi Sharma;Chandrakalavathi Thota;Ding Ding-Ding;Xudong Fan
皮肤屏障功能障碍的早期诊断有助于提供及时的预防性护理，以预防疾病，如特应性皮炎，牛皮癣，食物过敏和其他特应性皮肤病。皮肤屏障功能通常通过测量通过角质层的经表皮水分损失（TEWL）来评估，这是由于其非侵入性特性。然而，现有的商业TEWL装置受到许多因素的显著影响，例如环境温度、湿度、气流、水积聚、皮肤表面上的初始水含量、庞大的尺寸、高成本和对良好控制的环境的要求。在这里，我们开发了一个可穿戴的封闭室湿度计为基础的TEWL设备（可穿戴分析皮肤探针，WASP）和相关的算法，准确和连续监测皮肤水蒸气通量。在每次水蒸气通量测量之前，WASP使用短时间的干燥空气吹扫来干燥皮肤表面和腔室。其设计确保了高度受控的局部环境，例如皮肤表面和腔室的一致初始干燥条件。我们进一步应用WASP来测量一小群人类参与者的六个不同位置的水蒸气通量。发现WASP不仅可以测量和区分无感出汗（即，TEWL）和可感出汗（即，热出汗），而且还跟踪皮肤脱水-再水化循环。与商业TEWL设备，AquaFlux，比较表明，这两种设备获得的结果吻合良好。WASP将广泛应用于临床、美容和生物医学研究。
Early diagnosis of skin barrier dysfunction helps provide timely preventive care against diseases such as atopic dermatitis, psoriasis, food allergies, and other atopic skin disorders. Skin barrier function is commonly evaluated by measuring the transepidermal water loss (TEWL) through stratum corneum due to its noninvasive characteristics. However, existing commercial TEWL devices are significantly affected by many factors, such as ambient temperature, humidity, air flow, water accumulation, initial water contents on the skin surface, bulky sizes, high costs, and requirements for well-controlled environments. Here, we developed a wearable closed-chamber hygrometer-based TEWL device (Wearable Analytical Skin Probe, WASP) and the related algorithm for accurate and continuous monitoring of skin water vapor flux. The WASP uses short dry air purges to dry the skin surface and chamber before each water vapor flux measurement. Its design ensures a highly controlled local environment, such as consistent initial dry conditions for the skin surface and the chamber. We further applied WASP to measure the water vapor flux from six different locations of a small group of human participants. It is found that the WASP can not only measure and distinguish between insensible sweating (i.e., TEWL) and sensible sweating (i.e., thermal sweating) but also track skin dehydration-rehydration cycles. Comparisons with a commercial TEWL device, AquaFlux, show that the results obtained by both devices agree well. The WASP will be broadly applicable to clinical, cosmetic, and biomedical research.