DYNAMIC HISTOMORPHOMETRY OF ALVEOLAR BONE REMODELING IN THE ADULT-RAT
DYNAMIC HISTOMORPHOMETRY OF ALVEOLAR BONE REMODELING IN THE ADULT-RAT
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DOI：
10.1002/ar.1091960210
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发表时间：
1980-01-01
影响因子：
--
通讯作者：
BARON, R
中科院分区：
文献类型：
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作者：
VIGNERY, A;BARON, R
当牙齿以 6.7 μm/天的速度迁移时，牙槽骨通常在牙槽窝的一侧进行重塑，并在另一侧进行建模。牙周膜宽度保持恒定。由于这种高周转率，该骨骼是研究骨骼建模和重塑活动的良好模型。为了测量牙齿沿着大鼠牙槽骨迁移过程中发生的不同细胞事件，进行了组织形态测量，从而可以计算重塑周期每个阶段的持续时间，即吸收持续约 1.5 天，逆转持续约 3.5 天。由于形成阶段的持续时间约为1天，因此每个重塑周期的总持续时间约为6天。与成人骨小梁的 60-120 天相比，这个时间非常短。在该模型中，每个破骨细胞吸收2-4次。每天自己的骨量。在该大鼠牙槽骨模型中可以准确测量实验条件对骨细胞和骨重塑的影响。
Alveolar bone normally undergoes remodeling on 1 side of the socket and modeling on the opposite side as the tooth migrates at a rate of 6.7 .mu.m/day. Periodontal ligament width remains constant. Because of this high turnover rate, this bone is a good model to study bone modeling and remodeling activities. To measure the different cellular events occurring during tooth migration along the alveolar bone of the rat, histomorphometric measurements were performed which permitted calculation of the duration of each phase of the remodeling cycle, i.e., resorption lasts about 1.5 days and reversal about 3.5 days. Since the duration of the forming phase is about 1 day, the total duration of each remodeling cycle is about 6 days. This time is very short compared to 60-120 days in adult human trabecular bone. In this model each osteoclast resorbs 2-4 .times. its own volume of bone per day. Effects of experimental conditions on bone cells and bone remodeling can be accurately measured in this rat alveolar bone model.