Prevalence of Alzheimer's disease in a retirement community.
Prevalence of Alzheimer's disease in a retirement community.
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老年社区阿尔茨海默病的患病率。
DOI：
10.1093/oxfordjournals.aje.a114548
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发表时间：
1987
影响因子：
5
通讯作者：
Chance,JM
中科院分区：
文献类型：
--
作者：
Pfeffer,RI;Afifi,AA;Chance,JM
1980-1982年，在加州南部一个以中产阶级为主的白色退休社区，对817名65-99岁的成年人进行了一项旨在评估早期阿尔茨海默型老年性痴呆患病率的研究。基于162例神经系统诊断病例，目标人群中65岁以上人群中年龄和性别校正的阿尔茨海默病患病率为15.3%（95%置信区间= 13.0-17.5），80岁以上人群中为35.8%。对筛查程序未检测到的假阴性进行校正后，估计65岁以上人群的患病率为16.4%。诊断方法的有效性得到了后续研究的证实。这些发病率远远超过了过去对这一疾病的流行率估计。由于中晚期阿尔茨海默病的患病率可能被低估，本研究中的高患病率可能反映了早期疾病的相当大的社区负担。经年龄校正后，观察到的阿尔茨海默型老年痴呆症患病率男性高于女性，分别为19.1%和13.1%。在过去的许多临床调查中报告的女性优势可能是特有的晚期疾病，并反映了寻求护理和护理利用行为，而不是发病率的差异。
In a white, predominantly middle class southern California retirement community, 817 adults aged 65–99 years were evaluated in 1980–1982 in a study designed to assess prevalence of early Alzheimer-type senile dementia. Based on 162 neurologically diagnosed cases, the age- and sex-adjusted prevalence of Alzheimer's disease in the target population was 15.3% (95% confidence interval = 13.0–17.5) among persons aged 65+ years and 35.8% among persons aged 80+ years. Age-adjusted correction for false negatives not detected by a screening procedure yields an estimated prevalence of 16.4% in persons aged 65+ years. Validity of the diagnostic approach was confirmed by a follow-up study. These rates far exceed past prevalence estimates for this disease. Since prevalence of mid- and laterstages of Alzheimer's disease may have been underestimated, the high rates in this study may reflect a considerable community burden of early disease. Observed prevalence of Alzheimer-type senile dementia was higher among men than women after adjustment for age, 19.1% and 13.1%, respectively. The female predominance reported in many past clinical surveys may be peculiar to late disease and reflect care-seeking and care-utilization behaviors, rather than differences in incidence.