Malignant extragastrointestinal stromal tumor presenting as a vaginal mass: report of an unusual case with literature review
Malignant extragastrointestinal stromal tumor presenting as a vaginal mass: report of an unusual case with literature review
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表现为阴道肿块的恶性胃肠道间质瘤：一例罕见病例报告并文献复习
DOI：
10.1136/ijgc-00009577-200511000-00031
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
E. Gaertner
中科院分区：
文献类型：
--
作者：
E. Weppler;E. Gaertner
我们讨论了表现为阴道肿块的恶性胃肠道外间质瘤的临床和病理特征。患者为66岁女性，表现为阴道大量出血和阴道内肿瘤组织自发通过。组织学检查显示有丝分裂活跃的梭形细胞肿瘤。免疫组织化学分析显示肿瘤CD117(跨膜酪氨酸激酶)和CD34阳性，与胃肠道外恶性间质瘤一致。随后的临床检查发现一个8厘米长的阴道后壁肿块，可能起源于直肠阴道隔。此病例是独一无二的，以妇科主诉和病变的不寻常解剖位置为主要表现。对胃肠道外间质瘤的病理特征和预测其生物学行为的因素进行了综述。鉴于伊马替尼对不能切除的肿瘤患者可能的有效治疗，强调正确的肿瘤诊断。
The clinical and pathologic features of a malignant extragastrointestinal stromal tumor presenting as a vaginal mass are discussed. A 66-year-old female presented with copious vaginal bleeding and spontaneous passage of tumoral tissue per vagina. Histologic assessment showed a mitotically active spindle cell neoplasm. Immunohistochemical analysis demonstrated the neoplasm to be positive for CD117 (transmembrane tyrosine kinase) and CD34, consistent with a malignant extragastrointestinal stromal tumor. Subsequent clinical examination revealed an 8-cm posterior vaginal wall mass, with probable origin from the rectovaginal septum. This case is unique based on the primacy of presenting gynecologic complaints, and the unusual anatomic location of the lesion. A literature review of the pathologic features of extragastrointestinal stromal tumors and factors predictive of biologic behavior are discussed. Correct tumor diagnosis is emphasized given the effective treatment possible with imatinib for patients with unresectable tumors.