Karyotype studies of cutaneous T cell lymphoma: evidence for clonal origin.
Karyotype studies of cutaneous T cell lymphoma: evidence for clonal origin.
复制标题
皮肤 T 细胞淋巴瘤的核型研究：克隆起源的证据。
DOI：
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发表时间：
1979
影响因子：
6.5
通讯作者：
Dorothy Warburton
中科院分区：
文献类型：
--
作者：
R. L. Edelson;Carole L. Berger;Jahangir Raafat;Dorothy Warburton
Neoplastic lymphocytes from 3 patients with widespread cutaneous T cell lymphoma were karyotyped, using a chromosome banding technique. None of the patients had previously received chemotherapy. Morphologically homogeneous populations of abnormal T cells were available from 2 distinct body regions of 2 of the individuals and from the bone marrow of the third. Karyotypes from each of the 3 patients indicated monoclonality of their lymphoma. These observations suggest that extracutaneous dissemination of cutaneous T cell lymphoma involves spread of neoplastic cells derived from a single clone. If future studies can demonstrate that those neoplastic T cells actually localized in the skin are also progeny of a single malignant cell, a widely accepted concept that cutaneous T cell lymphoma is of multifocal origin will have to be reexamined.
