Epidemiology and Genetic Risk Factors of Drug Hepatotoxicity.
Epidemiology and Genetic Risk Factors of Drug Hepatotoxicity.
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DOI：
10.1016/j.cld.2016.08.004
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发表时间：
2017-03
影响因子：
5.1
通讯作者：
Odin JA
中科院分区：
文献类型：
--
作者：
Ahmad J;Odin JA
来自处方药和草药及膳食补充剂的特异质DILI的年发病率约为20例/100，000/年。然而，DILI的风险因药物而异。在美国和欧洲，抗菌药物是最常见的相关药物，阿莫西林/克拉维酸最常见，而在亚洲国家，草药和膳食补充剂占主导地位。几个人口统计学因素与DILI的风险以及严重程度和结局相关。DILI的遗传分析目前是有限的，但HLA基因和药物代谢和转运相关基因的多个多态性已被确定为DILI的危险因素。特异质DILI的流行病学表明，总体而言，这是一种罕见事件。在美国和欧洲，处方抗菌药物是最常见的原因，但HDS与DILI的相关性越来越高，特别是在韩国和日本。损伤的模式根据所涉及的药物而不同。DILI的风险在人口统计学因素方面存在明显差异，其中一些因素影响损伤的严重程度及其结局。DILI的遗传分析是有限的，虽然几个大的研究正在进行中。HLA基因和药物代谢转运相关基因的多态性是DILI的危险因素。
Idiosyncratic DILI from prescription medications and herbal and dietary supplements has an annual incidence rate of approximately 20 cases per 100,000 per year. However, the risk of DILI varies greatly according to the drug. In the US and Europe antimicrobials are the commonest implicated agents, with amoxicillin/clavulanate the most common, while in Asian countries herbal and dietary supplements predominate. Several demographic factors are associated with the risk of DILI as well as the severity and outcome. Genetic analysis of DILI is currently limited but multiple polymorphisms of HLA genes and genes involved in drug metabolism and transport have been identified as risk factors for DILI. The epidemiology of idiosyncratic DILI suggests that overall it is an uncommon event. In the US and Europe, prescription antimicrobials are the most common cause but HDS are increasingly associated with DILI, particularly in Korea and Japan. The pattern of injury differs according to the implicated drug. Several differences are apparent in the risk of DILI with regards to demographic factors and some of these factors influence the severity of the injury and its outcome. Genetic analysis of DILI is limited although several large studies are ongoing. Multiple polymorphisms of HLA genes and genes involved in drug metabolism and transport have been identified as risk factors for DILI.
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影响因子：
25.7
作者：
Bjornsson, Einar;Jacobsen, Elin I.;Kalaitzakis, Evangelos
通讯作者：
Kalaitzakis, Evangelos
DOI：
10.1093/cid/cit021
发表时间：
2013-05
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Carr DF;Chaponda M;Jorgensen AL;Castro EC;van Oosterhout JJ;Khoo SH;Lalloo DG;Heyderman RS;Alfirevic A;Pirmohamed M
通讯作者：
Pirmohamed M
影响因子：
13.5
作者：
Isabel Lucena, M.;Andrade, Raul J.;Hidalgo, Ramon
通讯作者：
Hidalgo, Ramon
影响因子：
13.5
作者：
Huang, YS;Chern, HD;Lee, SD
通讯作者：
Lee, SD
影响因子：
29.4
作者：
Andrade, RJ;Lucena, MI;Martin-Vivaldi, R
通讯作者：
Martin-Vivaldi, R