Prevalence of decreased kidney function in Chinese adults aged 35 to 74 years
Prevalence of decreased kidney function in Chinese adults aged 35 to 74 years
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DOI：
10.1111/j.1523-1755.2005.00757.x
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发表时间：
2005-12-01
影响因子：
19.6
通讯作者：
He, J
中科院分区：
文献类型：
--
作者：
Chen, J;Wildman, RP;He, J
背景慢性肾脏病（CKD）是西方国家的主要公共卫生负担，但对其在发展中国家的影响知之甚少。我们估计了CKD在中国普通成年人群中的患病率和绝对负担。本研究于2000年和2001年对15,540名年龄在35岁至74岁之间的中国成年人进行了横断面调查。在校准至Cleveland Clinic Foundation实验室的中心实验室，使用改良的动力学Jaffe反应法测量血清肌酐。使用肾脏疾病饮食改良研究开发的简化方程估计肾小球滤过率（GFR）。CKD定义为GFR < 60 mL/min/1.73m2。总体而言，在35至74岁的中国成年人中，GFR 60至89，30至59和< 30 mL/min/1.73 m（2）的年龄标准化患病率分别为39.4%，2.4%和0.14%。CKD（GFR < 60 mL/min/1.73 m2）的总患病率为2.53%，代表11，966，653人（男性1.31%或3，185，330人，女性3.82%或8，781，323人）。在35 - 44岁、45 - 54岁、55 - 64岁和65 - 74岁人群中，CKD的年龄别患病率分别为0.71%、1.69%、3.91%和8.14%。城乡居民CKD的年龄标化患病率相似（2.60%和2.52%），但华南地区CKD患病率（3.05%）高于华北地区（1.78%）。尽管中国CKD的患病率相对较低，但人群绝对负担很大。这些数据保证了一项旨在检测、预防和治疗中国CKD的国家计划。
Background. Chronic kidney disease (CKD) is a major public health burden in Western countries but little is known about its impact in developing countries. We estimated the prevalence and absolute burden of CKD in the general adult population in China.Methods. A cross-sectional survey was conducted in a nationally representative sample of 15,540 Chinese adults aged 35 to 74 years in 2000 and 2001. Serum creatinine was measured using the modified kinetic Jaffe reaction method at a central laboratory calibrated to the Cleveland Clinic Foundation laboratory. Glomerular filtration rate (GFR) was estimated using the simplified equation developed by the Modification of Diet in Renal Disease study. CKD was defined as an estimated GFR < 60 mL/min/1.73m(2).Results. Overall, the age-standardized prevalences of GFR 60 to 89, 30 to 59, and < 30 mL/min/1.73m(2) were 39.4%, 2.4%, and 0.14%, respectively, in Chinese adults aged 35 to 74 years. The overall prevalence of CKD (GFR < 60 mL/min/1.73m(2)) was 2.53%, representing 11,966,653 persons (1.31% or 3,185,330 men and 3.82% or 8,781,323 women). The age-specific prevalence of CKD was 0.71%, 1.69%, 3.91%, and 8.14% among persons 35 to 44, 45 to 54, 55 to 64, and 65 to 74 years old, respectively. The age-standardized prevalence of CKD was similar in urban (2.60%) and rural (2.52%) residents but was higher in south China (3.05%) than in north China (1.78%) residents.Conclusion. Although the prevalence of CKD in China was relatively low, the population absolute burden is substantial. These data warrant a national program aimed at detection, prevention, and treatment of CKD in China.