THE ROLE OF CHOLESTERYL ESTER TRANSFER PROTEIN IN PRIMATE APOLIPOPROTEIN-A-I METABOLISM - INSIGHTS FROM STUDIES WITH TRANSGENIC MICE
THE ROLE OF CHOLESTERYL ESTER TRANSFER PROTEIN IN PRIMATE APOLIPOPROTEIN-A-I METABOLISM - INSIGHTS FROM STUDIES WITH TRANSGENIC MICE
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DOI：
10.1161/01.atv.12.6.736
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发表时间：
1992-06-01
期刊：
影响因子：
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通讯作者：
MELCHIOR, GW
中科院分区：
文献类型：
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作者：
MAROTTI, KR;CASTLE, CK;MELCHIOR, GW
To assess the effects of cholesteryl ester transfer protein (CETP) on the primate lipoprotein profile, a transgenic mouse expressing cynomolgus monkey CETP was developed. The C57BL/6 mouse was used, and four lines expressing the primate CETP were established. The level of CETP activity in the plasma of the transgenic mice ranged from values similar to those obtained for the monkey to levels approximately sixfold higher than that in the normal monkey. When all of the lines were taken into consideration, there was a strong (r=-0.81 or higher, p
