REM LATENCY IN ALZHEIMERS-DISEASE
REM LATENCY IN ALZHEIMERS-DISEASE
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DOI：
10.1016/0006-3223(89)90179-0
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发表时间：
1989-02-01
影响因子：
10.6
通讯作者：
DEMENT, WC
中科院分区：
文献类型：
--
作者：
BLIWISE, DL;TINKLENBERG, J;DEMENT, WC
快速眼动睡眠（REML）第一次发作的潜伏期已被提出作为阿尔茨海默病（AD）的潜在生物标志物。在这项研究中，我们比较了28例AD患者和28例年龄和性别匹配的对照组的REML值。我们采用了REML的多种定义和多个截止值来对患者和对照进行分类。结果表明，最好的REML定义和最佳截止标准导致只有65%的正确分类。我们讨论了较长的REML在AD患者相对于对照组的整体睡眠障碍和选择性恶化的REM胆碱能系统。由于REML在其他形式的精神病理学中可能相对较短（例如，情感障碍），REML可能仍然有希望在痴呆和假性痴呆的鉴别诊断。
Latency to the first episode of rapid eye movement sleep (REML) has been proposed as a potential biomarker for Alzheimer''s disease (AD). In this study, we compared REML values for 28 AD patients and 28 age- and sex-matched controls. We employed multiple definitions of REML and multiple cutoffs to classify patients and controls. Results indicated that the best REML definition and optimal cutoff criterion resulted in only 65% correct classifications. We discuss the longer REML in AD patients relative to controls in terms of both overall sleep disturbance and selective deterioration of the REM-cholinergic system. As REML may be relatively short in other forms of psychopathology (e.g., affective disorders), REML may still hold promise in the differential diagnosis of dementia and pseudodementia.