Next Steps for Immunotherapy in Glioblastoma.
Next Steps for Immunotherapy in Glioblastoma.
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DOI：
10.3390/cancers14164023
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发表时间：
2022-08-20
期刊：
影响因子：
5.2
通讯作者：
Lukas, Rimas, V
中科院分区：
文献类型：
--
作者：
Cao, Toni Q.;Wainwright, Derek A.;Lee-Chang, Catalina;Miska, Jason;Sonabend, Adam M.;Heimberger, Amy B.;Lukas, Rimas, V
尽管目前的治疗标准，胶质母细胞瘤患者的预后仍然很差。最近的研究集中在免疫疗法上，这种疗法利用患者的免疫系统来靶向癌细胞。虽然免疫疗法被证明在非中枢神经系统癌症中是成功的，但到目前为止，对胶质母细胞瘤的免疫治疗结果令人失望。多种因素在胶质母细胞瘤的免疫治疗中发挥作用，成为新的研究领域。在这里，我们回顾了历史和新兴的免疫治疗方法，以及已被证明影响免疫治疗效果的分子因素。接受标准护理治疗的胶质母细胞瘤(GBM)患者的结果仍然很差。在这里，我们讨论以前研究的胶质母细胞瘤的免疫疗法组合，包括疫苗疗法和检查点抑制剂，以及新出现的治疗方法。此外，我们还探讨了可能影响免疫治疗反应的因素，这些因素应在未来旨在提高免疫治疗疗效的研究中加以考虑。
Prognosis for glioblastoma patients remains poor despite the current standard of care treatments. More recent investigations have focused on immunotherapy, which utilizes a patient’s immune system to target cancer cells. Though proven to be successful in non-central nervous system cancers, immunotherapies have yielded disappointing results for glioblastoma thus far. A variety of factors play into the efficacy of immunotherapy for glioblastoma and have become new areas of interest. Here we review both historical and emerging immunotherapeutic approaches, as well as the molecular factors that have been shown to impact the efficacy of immunotherapies. Outcomes for glioblastoma (GBM) patients undergoing standard of care treatment remain poor. Here we discuss the portfolio of previously investigated immunotherapies for glioblastoma, including vaccine therapy and checkpoint inhibitors, as well as novel emerging therapeutic approaches. In addition, we explore the factors that potentially influence response to immunotherapy, which should be considered in future research aimed at improving immunotherapy efficacy.
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影响因子：
17.1
作者：
Allen E;Jabouille A;Rivera LB;Lodewijckx I;Missiaen R;Steri V;Feyen K;Tawney J;Hanahan D;Michael IP;Bergers G
通讯作者：
Bergers G
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Parsa, Andrew T.
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作者：
Cabrita, Rita;Lauss, Martin;Jonsson, Goran
通讯作者：
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2.6
作者：
Cao M;Cabrera R;Xu Y;Liu C;Nelson D
通讯作者：
Nelson D
影响因子：
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作者：
Binder DC;Davis AA;Wainwright DA
通讯作者：
Wainwright DA