Age-Based Reference Ranges for Annual Height Velocity in US Children
Age-Based Reference Ranges for Annual Height Velocity in US Children
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DOI：
10.1210/jc.2013-4455
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发表时间：
2014-06-01
影响因子：
5.8
通讯作者：
Zemel, Babette S.
中科院分区：
文献类型：
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作者：
Kelly, Andrea;Winer, Karen K.;Zemel, Babette S.
目的：照顾儿童的临床医生依靠线性生长测量作为发育和整体健康的生物标志物。当前美国儿童身高速度 (HV) 的参考范围无法为早熟和晚熟儿童提供峰值速度年龄以外的 HV 百分位数或 Z 分数。我们提出了从当代美国青少年样本中根据经验获得的特定年龄的 HV 参考范围。 研究设计：受试者参加了儿童骨矿物质密度研究，这是一个来自美国的大型、多中心、多种族、当代儿童队列（入学时年龄为 5-19 岁），随访长达 7 年。大约 1500 名儿童每年（12 +/- 1 个月）进行了超过 4000 次 HV 测量。青春期状态是根据经验丰富的医疗服务提供者评估的乳房阶段或睾丸体积来确定的。使用 LMS 方法确定特定年龄的参考范围。 结果：为整个队列和青春期时间定义为“较早”、“平均”或“较晚”的亚组生成参考范围（第三至第 97 个百分位数）。与非非裔美国女孩相比，非裔美国女孩的青春期开始较早，年轻时的 HV 较高，老年时的 HV 较低；调整青春期时间后，差异并未持续存在。在男性中没有观察到这些差异。结论：这些年度 HV 参考范围可用于评估相对于同龄和性别同龄人的生长情况，并考虑青春期时间。还可以为群体研究确定 HV 的 Z 分数和精确百分位数。
Objective: Clinicians caring for children rely on measures of linear growth as a biomarker of development and overall health. Current reference ranges for height velocity (HV) for US children are unable to provide HV percentiles or Z-scores for early maturing and late maturing children at ages other than age at peak velocity. We present empirically acquired, age-specific reference ranges for HV from a contemporary sample of US youth.Study Design: Subjects were enrolled in the Bone Mineral Density in Childhood Study, a large, multicenter, multiethnic, contemporary cohort of children (aged 5-19 y at enrollment) from the United States followed for up to 7 years. More than 4000 annual (12 +/- 1 mo) HV measurements from approximately 1500 children were available. Pubertal status was determined by breast stage or testicular volume assessed by experienced health providers. Age-specific reference ranges were determined using the LMS method.Results: Reference ranges (third to 97th percentiles) were generated for the entire cohort and for subgroups whose pubertal timing was defined as "earlier," "average," or "later." African American girls experienced earlier pubertal onset and had greater HV at younger ages and lower HV at older ages, compared to non-African American girls; differences did not persist after adjustment for pubertal timing. These differences were not observed for males.Conclusions: These reference ranges for annual HV can be used to assess growth relative to peers of the same age and sex, with consideration of pubertal timing. Z-scores and exact percentiles for HV can also be determined for population studies.