Socioeconomic status and the association between arsenic exposure and type 2 diabetes
Socioeconomic status and the association between arsenic exposure and type 2 diabetes
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DOI：
10.1016/j.envres.2019.03.013
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发表时间：
2019-05-01
影响因子：
8.3
通讯作者：
Steinmaus, Craig
中科院分区：
文献类型：
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作者：
Eick, Stephanie M.;Ferreccio, Catterina;Steinmaus, Craig
目的：评估砷相关糖尿病风险是否在低社会经济地位和高社会经济地位（SES）人群之间存在差异。方法：我们使用了2007年10月至2010年12月在智利北方进行的基于人群的癌症病例对照研究（N = 1301）中收集的数据，该地区砷水浓度高（> 800 μ g/L），并有过去暴露的全面记录。通过结构化访谈、问卷调查和居住史获得了有关终生暴露和潜在混杂因素的信息。2型糖尿病定义为医生诊断的糖尿病或口服降糖药物使用。社会经济地位是用一个14分制的量表来衡量的，该量表基于家用电器、汽车、互联网接入或使用家政服务的情况。Logistic回归被用来评估砷和糖尿病之间的关系分层的SES.Results：在那些低SES，糖尿病的优势比（OR）比较个人在最高至最低三分位数的终身平均砷暴露为2.12（95%置信区间（CI）1.29-3.49，p = 0.004）。然而，那些在高SES组的风险并没有增加（OR = 1.12 [95%CI = 0.72-1.73]）。结论：我们的研究结果提供的证据表明，砷相关的糖尿病的风险可能更高，在智利的人低与高SES。
Objective: Evaluate whether arsenic-related diabetes risks differ between people of low and high socioeconomic status (SES).Methods: We used data collected between October 2007-December 2010 from a population-based cancer case-control study (N = 1301) in Northern Chile, an area with high arsenic water concentrations ( > 800 mu g/L) and comprehensive records of past exposure. Information on lifetime exposure and potential confounders were obtained using structured interviews, questionnaires, and residential histories. Type 2 diabetes was defined as physician-diagnosed diabetes or oral hypoglycemic medication use. SES was measured using a 14-point scale based on ownership of household appliances, cars, internet access, or use of domestic help. Logistic regression was used to assess the relationship between arsenic and diabetes within strata of SES.Results: Among those with low SES, the odds ratio (OR) for diabetes comparing individuals in the highest to lowest tertile of lifetime average arsenic exposure was 2.12 (95% confidence interval (CI) 1.29-3.49, p = 0.004). However, those in the high SES group were not at increased risk (OR = 1.12 [95% CI = 0.72-1.73]).Conclusions: Our findings provide evidence that risks of arsenic-related diabetes may be higher in Chile in people with low versus high SES.