Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines
Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines
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用环二 GMP 靶向 STING 大大增强了糖肽癌症疫苗的免疫反应
DOI：
10.1039/c8cc04860f
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发表时间：
2018
影响因子：
4.9
通讯作者：
Li Yan Mei
中科院分区：
文献类型：
--
作者：
Wu Jun Jun;Li Wen Hao;Chen Pu Guang;Zhang Bo Dou;Hu Hong Guo;Li Qian Qian;Zhao Lang;Chen Yong Xiang;Zhao Yu Fen;Li Yan Mei
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Cyclic di-GMP (CDG) was applied to MUC1 glycopeptide-based cancer vaccines with physical mixing and built-in (at 2′-OH of CDG) strategies for activating the STING pathway. CDG in both strategies behaved as a potent immunostimulant and contributed to high titers of IgG antibodies and the expression of multiple cytokines.