PPARα serves as a new receptor of aspirin for neuroprotection.
PPARα serves as a new receptor of aspirin for neuroprotection.
复制标题
PPARα 是阿司匹林的新受体，具有神经保护作用。
DOI：
10.1002/jnr.24561
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发表时间：
2020
影响因子：
4.2
通讯作者：
Pahan,Kalipada
中科院分区：
文献类型：
--
作者：
Patel,Dhruv;Roy,Avik;Pahan,Kalipada
Acetyl salicylic acid, commonly known as aspirin, has been being widely used as an anti‐inflammatory drug for almost 100 years. However, there was no receptor known for this popular drug. Recently, we have established that peroxisome proliferator‐activated receptor alpha (PPARα) acts as a novel receptor of aspirin. Activation of PPARα by aspirin stimulated a series of downstream signaling pathways that could potentially ameliorate different Alzheimer's disease (AD)‐related pathologies. In this mini‐review, we have discussed how aspirin–PPARα interaction plays a pivotal role in the amelioration of AD pathology via the stimulation of neurotrophic factors, upregulation of plasticity‐associated genes, and removal of plaque burden in hippocampal neurons.
