Correlation between high FBXW7 expression in pretreatment biopsy specimens and good response to chemoradiation therapy in patients with locally advanced esophageal cancer: A retrospective study
Correlation between high FBXW7 expression in pretreatment biopsy specimens and good response to chemoradiation therapy in patients with locally advanced esophageal cancer: A retrospective study
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DOI：
10.1002/jso.25127
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发表时间：
2018-07-01
影响因子：
2.5
通讯作者：
Kuwano, Hiroyuki
中科院分区：
文献类型：
--
作者：
Gombodorj, Navchaa;Yokobori, Takehiko;Kuwano, Hiroyuki
背景和目的：食管鳞状细胞癌（ESCC）对放化疗具有良好的反应性。F-Box和WD Repeat Domain Containing 7（FBXW 7）的失调与癌细胞中的治疗抗性相关。然而，FBXW 7表达与临床ESCC患者CRT敏感性之间的相关性仅在少数研究中进行了研究。因此，本研究的目的是阐明FBXW 7表达的意义，在预处理活检标本与食管鳞癌患者接受CRT。方法：我们调查了30个预处理活检标本的组织学分级后CRT手术切除肿瘤的FBXW 7表达和CRT敏感性之间的关系。此外，我们评估了FBXW 7高表达对体外ESCC细胞对细胞毒性药物（包括多西他赛和奈达铂）和放射的敏感性的影响。结果：晚期ESCC患者CRT前FBXW 7高表达与良好的病理CRT反应相关（P
Background and Objectives: Esophageal squamous cell carcinoma (ESCC) exhibits good reactivity to chemoradiation therapy (CRT). The dysregulation of F-Box and WD Repeat Domain Containing 7 (FBXW7) is associated with therapeutic resistance in cancer cells. However, the correlation between FBXW7 expression and CRT sensitivity in patients with clinical ESCC has been investigated only in few studies. Therefore, this study aimed to elucidate the significance of FBXW7 expression in pretreatment biopsy specimens from patients with ESCC receiving CRT.Methods: We investigated the relationship between FBXW7 expression and CRT sensitivity in 30 pretreatment biopsy specimens with histological grades of post-CRT surgically resected tumors. Furthermore, we evaluated the effects of high FBXW7 expression on the sensitivity to cytotoxic agents, including docetaxel and nedaplatin, and radiation in ESCC cells in vitro.Results: High FBXW7 expression before CRT correlated with a good pathological CRT response in patients with advanced ESCC (P