Coupling blood flow and neural function in the retina: a model for homeostatic responses to ocular perfusion pressure challenge.
Coupling blood flow and neural function in the retina: a model for homeostatic responses to ocular perfusion pressure challenge.
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DOI：
10.1002/phy2.55
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发表时间：
2013-08
影响因子：
2.5
通讯作者：
Bui, Bang V
中科院分区：
文献类型：
--
作者：
He, Zheng;Lim, Jeremiah K H;Nguyen, Christine T O;Vingrys, Algis J;Bui, Bang V
视网膜功能比血流对急性眼灌注压（OPP）降低的抵抗力更强。为了了解血流和神经功能之间脱节的机制，本研究建立了一个数学模型，该模型提出增加的氧气提取比补偿相对缺血以维持视网膜功能。此外，该模型还包含了一个术语，用于解释当眼压（IOP）升高实现OPP降低时神经元上的压力相关机械应力。我们表明，该模型结合了眼血流量、氧气提取比和IOP对神经元的机械应力，可以在大范围的OPP操作中解释视网膜功能。在急性OPP操作过程中，同时测量眼血流量、氧张力和视网膜功能，根据实验数据对模型的鲁棒性进行了测试。该模型为理解视网膜对短期OPP刺激的血流动力学反应提供了基础。
Retinal function is known to be more resistant than blood flow to acute reduction of ocular perfusion pressure (OPP). To understand the mechanisms underlying the disconnect between blood flow and neural function, a mathematical model is developed in this study, which proposes that increased oxygen extraction ratio compensates for relative ischemia to sustain retinal function. In addition, the model incorporates a term to account for a pressure-related mechanical stress on neurons when OPP reduction is achieved by intraocular pressure (IOP) elevation. We show that this model, combining ocular blood flow, oxygen extraction ratio, and IOP mechanical stress on neurons, accounts for retinal function over a wide range of OPP manipulations. The robustness of the model is tested against experimental data where ocular blood flow, oxygen tension, and retinal function were simultaneously measured during acute OPP manipulation. The model provides a basis for understanding the retinal hemodynamic responses to short-term OPP challenge.