Molecular basis of juvenile hormone signaling
Molecular basis of juvenile hormone signaling
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DOI：
10.1016/j.cois.2015.08.004
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发表时间：
2015-10-01
影响因子：
5.3
通讯作者：
Shinoda, Tetsuro
中科院分区：
文献类型：
--
作者：
Jindra, Marek;Belles, Xavier;Shinoda, Tetsuro
尽管保幼激素（JH）在昆虫中发挥着重要作用，但其作用机制直到最近才为人所知。一个突破是证明了bHLH-PAS蛋白Met是JH的细胞内受体。JH与Met的结合触发Met与其伴侣蛋白Tai的二聚化，并且所得复合物诱导靶基因的转录。此外，JH可以通过细胞膜第二信使信号磷酸化Met和Tai来增强这种反应。由JH-Met-Tai复合物诱导的一个重要基因是Kr-h1，其抑制变态。Kr-h1抑制一个“成人指定”基因E93。这种JH激活的途径在维持少年状态的行动是在早期胚胎后发育过程中，当幼虫/幼虫缺乏能力变质。
Despite important roles played by juvenile hormone (JH) in insects, the mechanisms underlying its action were until recently unknown. A breakthrough has been the demonstration that the bHLH-PAS protein Met is an intracellular receptor for JH. Binding of JH to Met triggers dimerization of Met with its partner protein Tai, and the resulting complex induces transcription of target genes. In addition, JH can potentiate this response by phosphorylating Met and Tai via cell membrane, second-messenger signaling. An important gene induced by the JH-Met-Tai complex is Kr-h1, which inhibits metamorphosis. Kr-h1 represses an 'adult specifier' gene E93. The action of this JH-activated pathway in maintaining the juvenile status is dispensable during early postembryonic development when larvae/nymphs lack competence to metamorphose.