A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza viruses
A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza viruses
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DOI：
10.1086/529522
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发表时间：
2008-04-15
影响因子：
6.4
通讯作者：
Sambhara, Suryaprakash
中科院分区：
文献类型：
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作者：
Hoelscher, Mary A.;Singh, Neetu;Sambhara, Suryaprakash
针对可能引起大流行的高致病性禽流感 H5N1 病毒开发有效的免疫原性疫苗是公共卫生的首要任务。如果发生流感大流行，全球对疫苗的需求将无法满足，因为生产鸡蛋疫苗的能力有限，而且胚胎鸡蛋的供应也存在潜在问题。因此，迫切需要开发替代的、不依赖鸡蛋的疫苗。我们开发了一种基于腺病毒载体的疫苗，其中含有来自进化枝 1 和进化枝 2 病毒的血凝素蛋白以及保守核蛋白，以扩大针对 H5N1 病毒的疫苗覆盖范围。
Development of effective and immunogenic vaccines against highly pathogenic avian influenza H5N1 viruses with the potential to cause a pandemic is a public health priority. The global demand for a vaccine cannot be met in the event of an influenza pandemic because of the limited capacity to manufacture egg-derived vaccines as well as potential problems with the availability of embryonated eggs. Thus, there is an urgent need to develop alternative, egg-independent vaccines. We developed an adenoviral vector-based vaccine that contains hemagglutinin protein from clade 1 and clade 2 viruses, as well as conserved nucleoprotein, to broaden the vaccine coverage against H5N1 viruses.