Complete genome sequence of Streptomyces sp. SCSIO 03032 isolated from Indian Ocean sediment, producing diverse bioactive natural products
Complete genome sequence of Streptomyces sp. SCSIO 03032 isolated from Indian Ocean sediment, producing diverse bioactive natural products
复制标题
链霉菌属的完整基因组序列。
DOI：
10.1016/j.margen.2020.100803
复制
发表时间：
2021
期刊：
影响因子：
1.9
通讯作者：
Zhu Yiguang
中科院分区：
文献类型：
--
作者：
Ma Liang;Zhang Wenjun;Liu Zhiwen;Huang Yanbing;Zhang Qingbo;Tian Xinpeng;Zhang Changsheng;Zhu Yiguang
链霉菌SCSIO 03032分离自印度洋深海沉积物样本（-3412米），产生几类生物活性化合物，包括α-吡啶酮抗生素（piericidins）、多环大环内酰胺（heronamides）和双吲哚生物碱（spiroindimicins、indimicins和lynamicins）。本文报道了链霉菌SCSIO 03032的全基因组序列，该菌株的线性染色体长度为6，287，975 bp。基因组分析揭示了存在29个推定的生物合成基因簇的次级代谢产物，包括piericidins，heronamides和spiroindimicins/indimicins/lynamicins。基因组序列表明，链霉菌SCSIO 03032可能是一个新的生物活性天然产物的生产商，在药物发现中具有潜在的应用。
Streptomyces sp. SCSIO 03032, isolated from a deep-sea sediment sample (−3412 m) from the Indian Ocean, produces several classes of bioactive compounds including α-pyridone antibiotics (piericidins), polycyclic macrolactams (heronamides) and bisindole alkaloids (spiroindimicins, indimicins and lynamicins). Here we report the complete genome sequence of Streptomyces sp. SCSIO 03032, which consists of a 6,287,975 bp linear chromosome. The genome analysis reveals the presence of 29 putative biosynthetic gene clusters for secondary metabolites, including those for piericidins, heronamides and spiroindimicins/indimicins/lynamicins. The genome sequence suggests that Streptomyces sp. SCSIO 03032 could be a producer for novel bioactive natural products with potential applications in drug discovery.