The dose-dependent pharmacokinetic profile of 2,4,5-trichlorophenoxy acetic acid following intravenous administration to rats.
The dose-dependent pharmacokinetic profile of 2,4,5-trichlorophenoxy acetic acid following intravenous administration to rats.
复制标题
大鼠静脉注射后 2,4,5-三氯苯氧基乙酸的剂量依赖性药代动力学特征。
DOI：
10.1016/0041-008x(76)90228-3
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发表时间：
1976
影响因子：
3.8
通讯作者：
P. J. Gehring
中科院分区：
文献类型：
--
作者：
M. W. Sauerhoff;W. Braun;G. Blau;P. J. Gehring
The clearance of 2,4,5-trichlorophenoxy acetic acid (2,4,5-T) from plasma and its elimination from the body of rats were determined after single intravenous doses of [14C]2,4,5-T. Dose-dependent pharmacokinetics were found. Urinary excretion of unchanged 2,4,5-T accounted for approx. 95% of the14C activity excreted from the body. The results show that the distribution, and elimination of 2,4,5-T are markedly altered when larger doses were administered. The pharmacokinetic data indicate that the statistical projection of results of experiments with large doses of 2,4,5-T, to predict the hazard of exposure to small amounts, is not justified because the capability of the body to handle the compound has been altered.
