The exposure data landscape for manufactured chemicals
The exposure data landscape for manufactured chemicals
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DOI：
10.1016/j.scitotenv.2011.10.046
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发表时间：
2012-01-01
影响因子：
9.8
通讯作者：
Hubal, Elaine A. Cohen
中科院分区：
文献类型：
--
作者：
Egeghy, Peter P.;Judson, Richard;Hubal, Elaine A. Cohen
美国环境保护局正在制定化学品筛选和优先排序计划，以快速有效地评估环境化学品对人类健康的潜在风险。作为这些努力的一部分，重要的是编目关于化学毒性和来自广泛来源的暴露的现有信息。这项分析的主要目标是确定暴露空间的重要方面，并对正在考虑作为美国环保局ToxCast(TM)筛选和优先排序计划一部分进行分析的化学品的可用暴露信息进行编目。公开的暴露数据已经被提取到ACTER(聚合计算毒理学资源)中，它结合了来自>；600公共来源的数十万种化学品的信息。我们使用ACTOR的数据来评估环境化学品的暴露数据环境。在至少有有限毒性信息的大约100,000种化学品中，只有不到五分之一的化学品也有暴露信息--对大多数这些信息来说，这些信息的效用有限(例如，生产量)。关于暴露相关介质中浓度的容易获得的数据仅适用于小得多的部分。其中，在水中测量到的化学物质数量最多，超过1150种独特化合物，其次是在土壤中测量到的788种物质，在空气中测量到的670种。这些较小的数字清楚地反映了资源的重点放在那些以前被确定为可能对人类健康构成危害的物质上。为了充分实现利用暴露信息指导毒性测试的设想目标，将需要测量接触更多的化学品。爱思唯尔出版公司(Elsevier B.V.)
The U.S. Environmental Protection Agency is developing chemical screening and prioritization programs to evaluate environmental chemicals for potential risk to human health in a rapid and efficient manner. As part of these efforts, it is important to catalog available information on chemical toxicity and exposure from widely dispersed sources. The main objective of this analysis is to define important aspects of the exposure space and to catalog the available exposure information for chemicals being considered for analysis as part of the U.S. EPA ToxCast (TM) screening and prioritization program. Publicly available exposure data have been extracted into ACToR (Aggregated Computational Toxicology Resource), which combines information for hundreds of thousands of chemicals from >600 public sources. We use data from ACToR to assess the exposure data landscape for environmental chemicals. Of the roughly 100,000 chemicals that have at least limited toxicity information available, less than one-fifth also have exposure information - and for most of these the information is of limited utility (e.g., production volume). Readily accessible data on concentrations in exposure-related media are only available for a much smaller fraction. Among these, the largest number of chemicals is measured in water with over 1150 unique compounds, followed by 788 substances measured in soil, and 670 in air. These small numbers clearly reflect a focus of resources on those substances previously identified as possibly posing a hazard to human health. Exposure to a much broader number of chemicals will need to be measured in order to fully realize the envisioned goal of using exposure information to guide toxicity testing. Published by Elsevier B.V.