Evidence for a class of very small introns in the gene for hypoxanthine-guanine phosphoribosyltransferase in Schistosoma mansoni.
Evidence for a class of very small introns in the gene for hypoxanthine-guanine phosphoribosyltransferase in Schistosoma mansoni.
复制标题
曼氏血吸虫次黄嘌呤鸟嘌呤磷酸核糖转移酶基因中存在一类非常小的内含子的证据。
DOI：
10.1093/nar/17.4.1635
复制
发表时间：
1989
影响因子：
14.9
通讯作者：
Wang,CC
中科院分区：
文献类型：
--
作者：
Craig3rd,SP;Muralidhar,MG;McKerrow,JH;Wang,CC
The single copy gene for the hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) of the parasitic trematode,Schistosoma mansoni, contains seven introns, the first four of which are only 31, 33, 42, and 32 bases in length. These are the smallest introns ever discovered in a non-viral nuclear gene coding for protein. These very small introns possess the canonical GT…AG splice site sequences but lack the branching sequence, the secondary structure, and the minimum size of approximately 50 bases believed to be required for the splicing of eucaryotic mRNA precursors. Evidently, a somewhat different splicing mechanism for the transcripts of these very small introns is necessary. Their discovery within the genes of helminths raises theoretical considerations for the evolution of introns in eucaryotes.
