Usefulness of the Two-Compartment Open Model in Pharmacokinetics

Usefulness of the Two-Compartment Open Model in Pharmacokinetics
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二室开放模型在药代动力学中的用途

DOI：
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发表时间：
1971
期刊：
影响因子：
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通讯作者：
C. Metzler
C. Metzler
中科院分区：
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文献类型：
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作者：
C. Metzler

文献摘要

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摘要 房室模型广泛应用于药物研究中，以定量药物的吸收、分布、代谢和排泄动力学。本文讨论了两室开放模型的两种应用。该讨论表明，尽管该模型极其简化且存在明显的弱点，但如果使用得当，它具有使其成为药物研究中有用工具的特性。
Abstract Compartment models are widely used in pharmaceutical research to quontitate the kinetics of absorption, distribution, metabolism and excretion of a drug. In this article two applications of the two compartment open model are discussed. This discussion shows that, in spite of the extreme simplification and obvious weaknesses of this model, it has properties that make it a useful tool in drug research when properly used.