NMDA receptor-independent control of transcription factors and gene expression.
NMDA receptor-independent control of transcription factors and gene expression.
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DOI：
10.1097/wnr.0b013e3283311db6
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发表时间：
2009-10-28
期刊：
影响因子：
1.7
通讯作者：
Dudek SM
中科院分区：
文献类型：
--
作者：
Adams JP;Robinson RA;Hudgins ED;Wissink EM;Dudek SM
突触可塑性的巩固似乎需要转录，但在这种情况下，细胞核是如何被告知的仍然是未知的。由于NMDA受体拮抗剂已被证明干扰动作电位的产生，是否需要一个突触产生的信号的核信号的问题是目前尚未解决。在这里，我们表明，在NMDA受体阻滞剂的药理学维持动作电位允许NMDA受体独立的转录因子结合和弧基因表达，这两者都被认为是NMDA受体依赖性。这些数据表明，以前归因于NMDA受体依赖性突触-核信号的核中的信号类型可以在NMDA受体依赖性突触可塑性不存在的情况下启动。
Consolidation of synaptic plasticity appears to require transcription, but how the nucleus is informed in this context remains unknown. Because NMDA receptor antagonists have been shown to interfere with action potential generation, the issue of whether or not a synaptically-generated signal is required for nuclear signaling is currently unresolved. Here we show that pharmacologic maintenance of action potentials during NMDA receptor blockade allows for NMDA receptor-independent transcription factor binding and arc gene expression, both of which were previously thought to be NMDA receptor dependent. These data suggest that types of signaling in the nucleus previously attributed to NMDA-receptor dependent synapse-to-nucleus signals can be initiated in the absence of NMDA-receptor dependent synaptic plasticity.