Flavor preferences conditioned by intragastric fructose and glucose - Differences in reinforcement potency
Flavor preferences conditioned by intragastric fructose and glucose - Differences in reinforcement potency
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DOI：
10.1016/s0031-9384(01)00442-5
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发表时间：
2001-04-01
影响因子：
2.9
通讯作者：
Sclafani, A
中科院分区：
文献类型：
--
作者：
Ackroff, K;Touzani, K;Sclafani, A
许多先前的条件反射研究表明，果糖与葡萄糖不同，进食后的强化作用最小。采用一种新的训练程序，限制饮食的大鼠每天交替训练20h，其中一种风味溶液(CS+F)与16%果糖灌胃(Od)配对，另一种口味(CS-)与IG水配对。在随后的两瓶测试中，他们显示出对CS+F的强烈偏好(85%)，而不是CS-。然后将第三种口味(CS+G)与IG 16%葡萄糖配对，这比CS+F更受欢迎。当每天用新口味与IG果糖、葡萄糖或水配对时，大鼠只学习CS+G偏好。当训练时间延长到每天20小时时，出现了CS+F偏好。新的大鼠每天训练20h，两瓶摄入CS+F，CS-与IG果糖和水配对，未能获得CS+F的偏好。其他大鼠在同时摄入CS+G和CS-的同时接受IG、葡萄糖和水的训练后，很快就形成了强烈的偏好。这些数据表明，果糖和葡萄糖都会产生进食后的强化信号，但果糖的信号比葡萄糖产生的信号弱和/或延迟。(C)2001 Elsevier Science Inc.保留所有权利。
Many prior conditioning studies indicate that fructose, unlike glucose, has minimal postingestive reinforcing effects. Using a new training procedure, food-restricted rats were trained in alternate 20-h/day sessions with one flavored solution (CS+F) paired with intragastric Od) infusions of 16% fructose and another flavor (CS-) paired with IG water. In subsequent two-bottle tests they showed a robust (85%) preference for the CS+F over the CS-. A third flavor (CS+G) was then paired with IG 16% glucose, and it was strongly preferred to the CS+F. When retrained 30 min/day with new flavors paired with IG fructose, glucose, or water the rats learned only a CS+G preference. When training was extended to 20 h/day, a CS+F preference developed. New rats trained 20 h/day with two-bottle access to CS+F and CS- paired with IG fructose and water failed to acquire a CS+F preference. Other rats rapidly developed a strong preference when trained with concurrent access to CS+G and CS- paired with IG glucose and water. These data indicate that both fructose and glucose generate postingestive reinforcing signals, but that the fructose signals are weaker and/or delayed relative to those produced by glucose. (C) 2001 Elsevier Science Inc. All rights reserved.