SERUM LEVEL, HALF-LIFE AND APPARENT VOLUME OF DISTRIBUTION OF DOXYCYCLINE IN GERIATRIC-PATIENTS
SERUM LEVEL, HALF-LIFE AND APPARENT VOLUME OF DISTRIBUTION OF DOXYCYCLINE IN GERIATRIC-PATIENTS
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DOI：
10.1007/bf00614205
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发表时间：
1986-01-01
影响因子：
2.9
通讯作者：
ESTLER, CJ
中科院分区：
文献类型：
--
作者：
BOCKER, R;MUHLBERG, W;ESTLER, CJ
测定了老年患者血清中多西环素的浓度、半衰期和表观分布容积。血清水平和表观分布容积高于年轻人的报告。表观分布容积与血清铁和β球蛋白水平相关。强力霉素与血清铁的结合对其药代动力学的可能影响进行了讨论。
The serum level, half-life and apparent volume of distribution of doxycycline were determined in geriatric patients. The serum level and apparent volume of distribution were higher than those reported for younger persons. The apparent volume of distribution was correlated with the serum iron and β-globulin levels. The possible influence of binding of doxycycline to serum iron on its pharmacokinetics is discussed.