Drug-resistant focal epilepsy in children is associated with increased modal controllability of the whole brain and epileptogenic regions.
Drug-resistant focal epilepsy in children is associated with increased modal controllability of the whole brain and epileptogenic regions.
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DOI：
10.1038/s42003-022-03342-8
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发表时间：
2022-04-28
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
--
作者：
网络控制理论提供了一个框架，通过该框架，大脑的神经生理动力学可以被建模为由扩散磁共振成像构建的结构连接体的函数。平均可控性描述的是一个区域将大脑驱动到容易到达的神经生理状态的能力，而模式可控性描述的是一个区域将大脑驱动到难以到达的状态的能力。在这项研究中，我们发现与健康对照组相比，耐药癫痫儿童的平均可控性和模式可控性增加。通过模拟，我们声称这些变化可能是丘脑皮质连接性增强的结果。在节点水平，我们展示了丘脑和后扣带区的模式可控性降低。在那些接受切除手术的患者中，我们还证明了切除包裹的模式可控性增加，这一发现特定于手术后癫痫发作缓解的患者。可控性的改变是癫痫患者大脑网络功能障碍的一种表现，可能是理解这种典型网络疾病的病理生理学的有用结构。了解这些可控性变化背后的机制也可能有助于设计以网络为重点的干预措施，寻求使网络结构和功能正常化。与健康对照组相比，耐药癫痫儿童表现出明显的结构连接和网络可控性的变化，为进一步了解这种疾病的病理生理学提供了进一步的见解。
Network control theory provides a framework by which neurophysiological dynamics of the brain can be modelled as a function of the structural connectome constructed from diffusion MRI. Average controllability describes the ability of a region to drive the brain to easy-to-reach neurophysiological states whilst modal controllability describes the ability of a region to drive the brain to difficult-to-reach states. In this study, we identify increases in mean average and modal controllability in children with drug-resistant epilepsy compared to healthy controls. Using simulations, we purport that these changes may be a result of increased thalamocortical connectivity. At the node level, we demonstrate decreased modal controllability in the thalamus and posterior cingulate regions. In those undergoing resective surgery, we also demonstrate increased modal controllability of the resected parcels, a finding specific to patients who were rendered seizure free following surgery. Changes in controllability are a manifestation of brain network dysfunction in epilepsy and may be a useful construct to understand the pathophysiology of this archetypical network disease. Understanding the mechanisms underlying these controllability changes may also facilitate the design of network-focussed interventions that seek to normalise network structure and function. Children with drug-resistant epilepsy exhibit distinct structural connectomes and changes in network controllability from healthy controls, providing further insight into the pathophysiology of this disease.
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影响因子：
3.5
作者：
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者：
Ghosh SS
影响因子：
3.7
作者：
Goñi J;Avena-Koenigsberger A;Velez de Mendizabal N;van den Heuvel MP;Betzel RF;Sporns O
通讯作者：
Sporns O
影响因子：
2.6
作者：
HAMDAN, AMA;NAYFEH, AH
通讯作者：
NAYFEH, AH
影响因子：
--
作者：
Blumenfeld, H
通讯作者：
Blumenfeld, H
影响因子：
25
作者：
Dworkin, Jordan D.;Linn, Kristin A.;Bassett, Danielle S.
通讯作者：
Bassett, Danielle S.