Photosensitized lysis of red blood cells by phototoxic antimalarial compounds.
Photosensitized lysis of red blood cells by phototoxic antimalarial compounds.
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光毒性抗疟化合物对红细胞进行光敏裂解。
DOI：
10.1111/j.1751-1097.1987.tb04733.x
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发表时间：
1987
影响因子：
3.3
通讯作者：
Sibley,MT
中科院分区：
文献类型：
--
作者：
Epling,GA;Sibley,MT
在存在红细胞的情况下，对12种光毒性喹啉甲醇抗疟药和其他3种非光毒性临床使用化合物进行辐照，以确定产生的溶血是否是光毒性的可靠预测因子。体内试验中最具光毒性的化合物也是本研究中最具光毒性的化合物。奎宁几乎不引起红细胞溶解，与其在人体中的非光毒性平行。喹啉甲醇诱导的光溶血在存在和不存在氧气的情况下都发生。用BHA和胆固醇富集RBC在保护细胞免受光溶血方面特别有效。其他化合物提供了一定程度的保护，而超氧化物歧化酶和叠氮化钠等，没有提供保护。
A family of 12 phototoxic quinolinemethanol antimalarials and three other non‐phototoxic clinically used compounds were irradiated in the presence of red blood cells to determine if the resulting hemolysis would be a reliable predictor of phototoxicity. The most phototoxic compounds fromin vivotests were also the most phototoxic in this study. Quinine caused little RBC lysis, paralleling its non‐phototoxicity in humans. The quinolinemethanol‐induced photohemolysis occurs both in the presence and absence of oxygen. Enriching the RBC with BHA and cholesterol was particularly effective at protecting the cells from photohemolysis. Other compounds offered some measure of protection, while superoxide dismutase and sodium azide, among others, afforded no protection.