After insulin binds.
After insulin binds.
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DOI：
10.1126/science.2442814
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发表时间：
1987-09
期刊：
影响因子：
56.9
通讯作者：
O. Rosen
中科院分区：
文献类型：
--
作者：
O. Rosen
与胰岛素作用机制相关的三个最新进展包括：（i）发现胰岛素受体是胰岛素依赖性蛋白酪氨酸激酶，在功能上与某些生长因子受体和癌基因编码的蛋白相关;（ii）胰岛素前受体互补DNA的分子克隆;（iii）证明受体的蛋白酪氨酸激酶活性对胰岛素作用是必需的。现在的努力集中在受体激酶的生理底物上。迄今为止的经验表明，它们将是罕见的蛋白质，其在完整细胞中的磷酸化可能是短暂的。试图剖析胰岛素作用的初始生化途径的优势包括关于胰岛素作用的代谢后果的丰富信息以及在果蝇和人类中进行遗传分析的潜力。
Three recent advances pertinent to the mechanism of insulin action include (i) the discovery that the insulin receptor is an insulin-dependent protein tyrosine kinase, functionally related to certain growth factor receptors and oncogene-encoded proteins, (ii) the molecular cloning of the insulin proreceptor complementary DNA, and (iii) evidence that the protein tyrosine kinase activity of the receptor is essential for insulin action. Efforts are now focusing on the physiological substrates for the receptor kinase. Experience to date suggests that they will be rare proteins whose phosphorylation in intact cells may be transient. The advantages of attempting to dissect the initial biochemical pathway of insulin action include the wealth of information about the metabolic consequences of insulin action and the potential for genetic analysis in Drosophila and in man.