Intravenous immunoglobulin therapy in acute disseminated encephalomyelitis
Intravenous immunoglobulin therapy in acute disseminated encephalomyelitis
复制标题
DOI：
10.1016/s0022-510x(99)00072-6
复制
发表时间：
1999-05-01
影响因子：
4.4
通讯作者：
Pandey, N
中科院分区：
文献类型：
--
作者：
Pradhan, S;Gupta, RP;Pandey, N
我们描述了4例急性播散性脑脊髓炎(ADEM)患者，在3-5天的大剂量甲基强的松龙静脉滴注无效后，接受了静脉免疫球蛋白(IVIg)治疗。所有患者的临床特征均提示预后不良，MRI表现提示脑白质广泛改变。两名患者也有脊髓受累，在病情急性期需要呼吸机支持。4例患者均顺利康复。恢复模式提示IVIg在暴发性急性心肌梗死中可能是有用的。需要进一步的试验来寻找静脉注射免疫球蛋白单独或与甲基强的松龙联合治疗ADEM的疗效。(C)1999 Elsevier Science B.V.保留所有权利。
We describe 4 patients with acute disseminated encephalomyelitis (ADEM) who were treated with intravenous immunoglobulins (IVIg) after getting no immediate response from a 3-5 day course of high dose intravenous methylprednisolone. All had clinical features to suggest poor prognosis and MRI findings to indicate extensive white matter changes in the brain. Two patients who had spinal cord involvement as well, required ventilatory support during acute phase of the illness. All the 4 patients recovered dramatically. Recovery pattern suggested that IVIg might be useful in fulminant ADEM. Further trials are needed to look for the efficacy of IVIg alone and in combination with methylprednisolone in the treatment of ADEM. (C) 1999 Elsevier Science B.V. All rights reserved.