Cerebrospinal fluid leptin in anorexia nervosa: Correlation with nutritional status and potential role in resistance to weight gain
Cerebrospinal fluid leptin in anorexia nervosa: Correlation with nutritional status and potential role in resistance to weight gain
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DOI：
10.1210/jc.82.6.1845
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发表时间：
1997-06-01
影响因子：
5.8
通讯作者：
Jimerson, DC
中科院分区：
文献类型：
--
作者：
Mantzoros, C;Flier, JS;Jimerson, DC
对啮齿动物的研究表明，瘦素在中枢神经系统中发挥作用，调节食物摄入和能量代谢。为了评估瘦素在神经性厌食症减肥中的可能作用，本研究比较了厌食症患者和对照者的脑脊液 (CSF) 和血浆瘦素浓度。受试者包括 11 名低体重和治疗后的神经性厌食症女性患者，以及 15 名健康女性对照。通过放射免疫分析（RIA）测量血液和脑脊液中瘦素的浓度。与对照组相比，神经性厌食症患者脑脊液中的瘦素浓度降低（98 +/- 26 与 160 +/- 58 pg/mL；P < 0.0005）和血浆中瘦素浓度降低（1.75 +/- 0.46 与 7.01 +/- 3.92 ng/mL；P < 0.005）。然而，患者的脑脊液与血浆瘦素比率（0.060 +/- 0.023）高于对照组（0.025 +/- 0.007；P < 0.0001）。在治疗后测试中，尽管患者体重尚未达到正常，但脑脊液和血浆瘦素浓度已升至正常水平。这些结果证明了神经性厌食症正能量平衡期间血浆和脑脊液瘦素的动态变化。结果进一步表明，在厌食症患者治疗期间，在体重完全恢复之前脑脊液瘦素水平正常化可能有助于抵抗体重增加和/或体重恢复不完全。
Studies in rodents have shown that leptin acts in the central nervous system to modulate food intake and energy metabolism. To evaluate the possible role of leptin in the weight loss of anorexia nervosa, this study compared cerebrospinal fluid (CSF) and plasma leptin concentrations in anorexic patients and controls. Subjects included 11 female patients with anorexia nervosa studied at low weight and after treatment, and 15 healthy female controls. Concentrations of leptin in blood and CSF were measured by RIA. Patients with anorexia nervosa, compared to controls, had decreased concentrations of leptin in CSF (98 +/- 26 vs. 160 +/- 58 pg/mL; P < 0.0005) and plasma (1.75 +/- 0.46 vs. 7.01 +/- 3.92 ng/mL; P < 0.005). The CSF to plasma leptin ratio, however, was higher for patients (0.060 +/- 0.023) than for controls (0.025 +/- 0.007; P < 0.0001). At posttreatment testing, although patients had not yet reached normal body weight, CSF and plasma leptin concentrations had increased to normal levels. These results demonstrate the dynamic changes in plasma and CSF leptin during positive energy balance in anorexia nervosa. The results further suggest that normalization of CSF leptin levels before full weight restoration during treatment of anorexic patients could contribute to resistance to weight gain and/or incomplete weight recovery.