Cerebral radiation necrosis
Cerebral radiation necrosis
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DOI：
10.1097/01.nrl.0000080951.78533.c4
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发表时间：
2003-07-01
期刊：
影响因子：
1.2
通讯作者：
Gilbert, MR
中科院分区：
文献类型：
--
作者：
Giglio, P;Gilbert, MR
背景-脑放射性坏死被认为是癌症放射治疗的潜在并发症至少有50年。神经放射学和组织病理学的进展有助于更全面地描述这个问题，一些治疗干预措施可能有助于防止这种病理的进展。这是很重要的，在实现一个最重要的目标，癌症护理维持生活质量。审查摘要-这篇评论讨论了我们的理解放射性坏死的演变，从第一个“尸检依赖”的报告，目前的特点，这些病变的磁共振（MR）和功能成像。综述分为两部分：第一部分介绍了放射性坏死的定义、发病率和推测的发病机制。第二部分包括基于影像学特征（包括功能影像学）和活检结果的诊断。管理选项也explored.CONCLUSIONS-放射性坏死是一个非常重要的并发症放射治疗脑癌，并可能对患者的生活质量产生巨大的影响。接受脑部放射治疗的患者放射性坏死的早期诊断随着当前的神经成像模式和对其病理生理学的更好理解而得到改善。治疗方式的发展较慢，但仍有希望。
BACKGROUND- Brain radiation necrosis has been recognized as a potential complication of radiation therapy for cancer for at least five decades. Advances in neuro-radiology and histopathology have helped characterize this problem more fully and some therapeutic interventions may help prevent progression of this pathology. This is important in achieving one of the most important goals of cancer care-maintaining quality of life.REVIEW SUMMARY- This review discusses the evolution of our understanding of radiation necrosis, from the first "autopsy-dependent" reports to the current characterization of these lesions with magnetic resonance (MR) and functional imaging. The review is presented in two parts; Part I deals with the definition, incidence and presumed pathogenesis of radiation necrosis. Part II includes diagnosis on the basis of imaging characteristics, (including functional imaging) and biopsy results. Management options are also explored.CONCLUSIONS- Radiation necrosis is a very significant complication of radiation treatment of brain cancers and may have a tremendous impact on a patient's quality of life. The early diagnosis of radiation necrosis in patients receiving radiation therapy to the brain has improved with current neuro-imaging modalities and better understanding of its pathophysiology. The development of treatment modalities has been slower, but is nonetheless promising.