Intra-arterial chemotherapy for head and neck cancer. An update on the totally implantable infusion pump.
Intra-arterial chemotherapy for head and neck cancer. An update on the totally implantable infusion pump.
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头颈癌的动脉内化疗。
DOI：
10.1001/archotol.1987.01860110049007
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
B. Medvec
中科院分区：
文献类型：
--
作者：
S. Baker;A. Forastiere;R. Wheeler;R. Wheeler;B. Medvec
动脉内化疗治疗头颈部局部恶性肿瘤是一种有吸引力的方法，原因如下。也许最重要的是获得区域优势的可能性，这样增加的药物浓度可以全身递送。因此，病人可能免于全身毒性。我们报告了我们在37例患者中使用完全植入式输液泵的累积经验。共植入42台泵，其中单导管泵28台，双导管泵14台。放射性核素显像显示所有患者肿瘤全灌注。顺铂（50 ~ 100mg /m2）联合氟尿定（0.01 ~ 0.045 mg/kg/d）治疗26例。对于这些大量预处理的患者，我们观察到在鳞状细胞癌患者亚组中有43%的完全和部分缓解率。这些结果与系统使用这些药物和治疗复发性疾病的其他药物组合所报告的结果相当。
Intra-arterial chemotherapy for the treatment of localized malignant neoplasms in the head and neck is an appealing approach for several reasons. Perhaps the most important is the possibility of obtaining a regional advantage such that an increased drug concentration is delivered systemically. The patient may, therefore, be spared systemic toxicity. We report our accumulated experience using a totally implantable infusion pump in 37 patients. A total of 42 pumps were implanted: 28 single-catheter pumps and 14 dual-catheter pumps. Radionuclide imaging demonstrated total perfusion of the tumor in all patients. A combination of cisplatin (50 to 100 mg/m2) and floxuridine (0.01 to 0.045 mg/kg/d) was used to treat 26 patients. For these heavily pretreated patients, we observed a 43% complete and partial response rate in the subgroup of patients with squamous cell carcinoma. These results are comparable with those reported for these drugs administered systemically and for other drug combinations tested in the treatment of recurrence disease.
头颈癌手术后的化疗。
DOI：
10.1097/00000421-198906000-00001
发表时间：
1989
期刊：
American journal of clinical oncology
影响因子：
--
作者：
Jacobs,JR;Pajak,TF;al-Sarraf,M;Kinzie,J;Stetz,J;Davis,LW;Leibel,S;Laramore,GE
通讯作者：
Laramore,GE